Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts.
文献类型：期刊论文
| 作者 | Zhao-Xin Wang ; John X. Zhang ; Qiu-Lin Wu ; Ning Liu ; Xiao-Ping Hu ; Raymond C.K. Chan ; Zhuang-Wei Xiao |
| 刊名 | Neuroimage
 |
| 出版日期 | 2010 |
| 卷号 | 49期号:1页码:971-976 |
| 通讯作者邮箱 | jxzhang@cuhk.edu.hk ; xiaozw@vip.163.com |
| 关键词 | Addiction Heroin Affective processing Emotion Amygdala Visual cortex |
| 产权排序 | 5 |
| 通讯作者 | J.X. Zhang，Z.-W. Xiao |
| 合作状况 | 国内 |
| 英文摘要 | Long-term exposure to drug may alter the neural system associated with affective processing, as evidenced by both clinical observations and behavioral data documenting dysfunctions in emotional experiences and processing in drug addicts. Although many imaging studies examined neural responses to drug or drug-related cues in addicts, there have been few studies explicitly designed to reveal their neural abnormalities in processing non-drug-related natural affective materials. The present study asked abstinent heroin addicts and normal controls to passively view standardized affective pictures of positive, negative, or neutral valence and compared their brain activities with functional MRI. Compared to normal controls, addicts showed reduced activation in right amygdala in response to the affective pictures, consistent with previous reports of blunted subjective experience for affective stimuli in addicts. Furthermore, in two visual cortical areas BA 19 and 37, while the controls showed greater responses to positive pictures than to negative ones replicating literature findings, the addicts showed the opposite pattern. The results reveal a complex pattern of altered processing of non-drug-related affective materials in addicts showing both heightened and blunted neural responses in different brain regions and for different stimulus valence. The present study highlights the importance of brain imaging research on drug addicts' processing of affective stimuli in understanding disruptions in their emotion circuitry. |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pubmed/19683582 |
| 语种 | 英语 |
| 公开日期 | 2014-06-09 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10059]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 推荐引用方式 GB/T 7714 | Zhao-Xin Wang,John X. Zhang,Qiu-Lin Wu,et al. Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts.[J]. Neuroimage,2010,49(1):971-976. |
| APA | Zhao-Xin Wang.,John X. Zhang.,Qiu-Lin Wu.,Ning Liu.,Xiao-Ping Hu.,...&Zhuang-Wei Xiao.(2010).Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts..Neuroimage,49(1),971-976. |
| MLA | Zhao-Xin Wang,et al."Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts.".Neuroimage 49.1(2010):971-976. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。