Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks
文献类型：期刊论文
| 作者 | He, Xingu1,2; Xiao, Lin1; Sui, Nan1 ; Nan Sui
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2010-02-10 |
| 卷号 | 627期号:1-3页码:136-141 |
| 通讯作者邮箱 | suin@psych.ac.cn |
| 关键词 | Morphine Conditioned place preference The medial striatum The intermediate medial mesopallium Reward-related learning Day-old chicks |
| ISSN号 | 0014-2999 |
| 产权排序 | 1 |
| 通讯作者 | Nan Sui |
| 合作状况 | 国内 |
| 中文摘要 | . |
| 英文摘要 | In the avian forebrain, the medial striatum and the intermediate medial mesopallium are thought to be important structures for associative learning in chicks, where the role of dopaminergic systems in learning processes has been verified in various behavioral paradigms, such as one-trial passive avoidance learning. However, it is not yet clear whether the dopaminergic system of these regions is responsible for associative learning underlying cue-elicited drug reward. In this study, a 6-day conditioning schedule in day-old chicks with i.p. morphine (2 mg/kg) was used to compare the effects of intracerebrally injected dopamine D(1) receptor antagonist, SCH23390, and D(2) antagonist, spiperone. The antagonists were injected bilaterally (3 mu g/site) into either the medial striatum or the intermediate medial mesopallium, and tests were conducted on morphine-induced conditioned place preference or locomotor activity. The acquisition of place preference was significantly inhibited by SCH23390 in either the medial striatum or the intermediate medial mesopallium, but not by spiperone. However, in the medial striatum, but not in the intermediate medial mesopallium, the locomotor activity was blocked by both SCH23390 and spiperone. These data suggest that the medial striatum and the intermediate medial mesopallium in birds are differentially involved in the rewarding effects of morphine, and similarly to mammals, the dopamine D(1) system may play an important role in the development of opiate reward. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved. |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274093800020 |
| 公开日期 | 2014-06-10 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10077]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Nan Sui |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xingu,Xiao, Lin,Sui, Nan,et al. Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,627(1-3):136-141. |
| APA | He, Xingu,Xiao, Lin,Sui, Nan,&Nan Sui.(2010).Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks.EUROPEAN JOURNAL OF PHARMACOLOGY,627(1-3),136-141. |
| MLA | He, Xingu,et al."Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks".EUROPEAN JOURNAL OF PHARMACOLOGY 627.1-3(2010):136-141. |
入库方式： OAI收割
来源：心理研究所
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