Neurological Soft Signs in Schizophrenia: A Meta-analysis
文献类型：期刊论文
| 作者 | Chan, Raymond C. K.1,2 ; Xu, Ting1,3,4; Heinrichs, R. Walter5; Yu, Yue1,6,7; Wang, Ya1,2
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| 刊名 | SCHIZOPHRENIA BULLETIN
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| 出版日期 | 2010-11-01 |
| 卷号 | 36期号:6页码:1089-1104 |
| 通讯作者邮箱 | rckchan@psych.ac.cn |
| 关键词 | neurological soft signs meta-analysis schizophrenia |
| ISSN号 | 0586-7614 |
| 产权排序 | 1 |
| 通讯作者 | Raymond C. K. Chan |
| 合作状况 | 国内 |
| 英文摘要 | Background: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting NSS and related data using standard measures in schizophrenia and healthy comparison groups. Method: A systematic search was conducted for published articles reporting data on the prevalence of NSS in schizophrenia using standard clinical rating scales and healthy comparison groups. Meta-analyses were performed using the Comprehensive Meta-analysis software package. Effect sizes (Cohen d) indexing the difference between schizophrenic patients and the healthy controls were calculated on the basis of reported statistics. Potential moderator variables evaluated included age of patient samples, level of education, sample sex proportions, medication doses, and negative and positive symptoms. Results: A total of 33 articles met inclusion criteria for the meta-analysis. A large and reliable group difference (Cohen d) indicated that, on average, a majority of patients (73%) perform outside the range of healthy subjects on aggregate NSS measures. Cognitive performance and positive and negative symptoms share 2%-10% of their variance with NSS. Conclusions: NSS occur in a majority of the schizophrenia patient population and are largely distinct from symptomatic and cognitive features of the illness. |
| 学科主题 | 变态心理学 |
| 收录类别 | SCI ; SSCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963054/ |
| 语种 | 英语 |
| WOS记录号 | WOS:000283683800007 |
| 公开日期 | 2014-06-16 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10106]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 4.Renmin Univ China, Sch Informat, Beijing, Peoples R China 5.York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada 6.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 7.Peking Univ, Yuanpei Coll, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,et al. Neurological Soft Signs in Schizophrenia: A Meta-analysis[J]. SCHIZOPHRENIA BULLETIN,2010,36(6):1089-1104. |
| APA | Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,Yu, Yue,&Wang, Ya.(2010).Neurological Soft Signs in Schizophrenia: A Meta-analysis.SCHIZOPHRENIA BULLETIN,36(6),1089-1104. |
| MLA | Chan, Raymond C. K.,et al."Neurological Soft Signs in Schizophrenia: A Meta-analysis".SCHIZOPHRENIA BULLETIN 36.6(2010):1089-1104. |
入库方式： OAI收割
来源：心理研究所
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