Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
文献类型：期刊论文
| 作者 | Liu, Zhenquan2; Li, Pengtao2; Zhao, Dan2; Tang, Huiling2; Guo, Jianyou1 ; Jianyou Guo
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| 刊名 | BEHAVIORAL AND BRAIN FUNCTIONS
 |
| 出版日期 | 2010-10-19 |
| 卷号 | 6期号:61页码:1-6 |
| 通讯作者邮箱 | guojianyou@126.com |
| ISSN号 | 1744-9081 |
| 产权排序 | 2 |
| 通讯作者 | Jianyou Guo |
| 合作状况 | 国内 |
| 中文摘要 | Background Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper. Methods The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively. Results Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury. Conclusions These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis. |
| 英文摘要 | Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper. |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | SCI |
| 原文出处 | http://link.springer.com/article/10.1186/1744-9081-6-61 |
| 语种 | 英语 |
| WOS记录号 | WOS:000284111400001 |
| 公开日期 | 2014-06-18 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10128]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Jianyou Guo |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2010,6(61):1-6. |
| APA | Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,Guo, Jianyou,&Jianyou Guo.(2010).Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.BEHAVIORAL AND BRAIN FUNCTIONS,6(61),1-6. |
| MLA | Liu, Zhenquan,et al."Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats".BEHAVIORAL AND BRAIN FUNCTIONS 6.61(2010):1-6. |
入库方式： OAI收割
来源：心理研究所
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