Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense
文献类型：期刊论文
| 作者 | Liu, Jie-Qing; Wang, Cui-Fang; Li, Yan ; Luo, Huai-Rong; Qiu, Ming-Hua
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2012-03-01 |
| 卷号 | 78期号:4页码:368-376 |
| 关键词 | Ganoderma sinense Ganodermataceae triterpenoids sesquiterpene cytotoxicity CYP3A4 induction |
| 英文摘要 | A new pentanorlanostane, ganosineniol A (1), eight new lanostane triterpenoids, ganosinoside A (2), ganoderic acid Jc (3), ganoderic acid Jd (4), ganodermatetraol (5), ganolucidic acid.a (6), ganolucidate F (7), ganoderiol J (8), and methyl lucidenate Ha (9), and a new sesquiterpenoid, ganosinensine (10), together with eleven known triterpenoids (11-21), were isolated from the fruiting bodies of the fungus Ganoderma sinense. Chemical structures were determined based on spectroscopic evidence, including 1D, 2D NMR, and mass spectral data. Furthermore, all isolates were tested for cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression. Among them, ganoderic acid Jc (3) displayed selective inhibitory activity against HL-60 cells (IC50 = 8.30 mu M), and ganoderiol E (11) exhibited selective cytotoxic activity against MCF-7 cells (IC50 = 6.35 mu M). Meanwhile, compounds 5, 7, and ganolucidic acids B and C (19, 20) showed induction ability of hPXR-mediated CYP3A4 expression. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | LUCIDUM FR KARST ; TUMOR-CELLS ; TRITERPENOIDS ; CONSTITUENTS ; ACID ; LANOSTANOIDS ; CYTOTOXICITY ; INHIBITION ; STEROIDS ; TSUGAE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301343700011 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/20446]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | Chinese Acad Sci, State Key Lab Photochem & Plant Resources W Chin, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jie-Qing,Wang, Cui-Fang,Li, Yan,et al. Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense[J]. PLANTA MEDICA,2012,78(4):368-376. |
| APA | Liu, Jie-Qing,Wang, Cui-Fang,Li, Yan,Luo, Huai-Rong,&Qiu, Ming-Hua.(2012).Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense.PLANTA MEDICA,78(4),368-376. |
| MLA | Liu, Jie-Qing,et al."Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense".PLANTA MEDICA 78.4(2012):368-376. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。