Huperserines A-E, Lycopodium alkaloids from Huperzia serrata
文献类型：期刊论文
| 作者 | Jiang, Wei-Wei1,2; Liu, Fei1,2 ; Gao, Xiu1,2; He, Juan1; Cheng, Xiao1; Peng, Li-Yan1; Wu, Xing-De1; Zhao, Qin-Shi1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 99页码:72-77 |
| 关键词 | Hupetzia serrate Lycopodium alkaloids Huperserines A-E Anti-AChE activity |
| 英文摘要 | A phytochemical study on Huperzia serrata led to the isolation of four new 5-deoxyfawcettimine-related Lycopodium alkaloids, huperserines A-D (1-4), and one new lycodine-type alkaloid, huperserine E (5). Their structures were elucidated based on spectroscopic data, including 1D and 2D NMR techniques. 5-Carbonyl or 5-hydroxyl group is a typical characteristic of lycopodine- and fawcettimine-type alkaloids. This is the first report of the 5-deoxyfawcettimine type Lycopodium alkaloids. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that huperserine E exhibited moderate anti-AChE activity with an IC50 value of 6.71 mu M. (C) 2014 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | PALHINHAEA-CERNUA ; CASUARINOIDES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347019000010 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/20464]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Wei-Wei,Liu, Fei,Gao, Xiu,et al. Huperserines A-E, Lycopodium alkaloids from Huperzia serrata[J]. FITOTERAPIA,2014,99:72-77. |
| APA | Jiang, Wei-Wei.,Liu, Fei.,Gao, Xiu.,He, Juan.,Cheng, Xiao.,...&Zhao, Qin-Shi.(2014).Huperserines A-E, Lycopodium alkaloids from Huperzia serrata.FITOTERAPIA,99,72-77. |
| MLA | Jiang, Wei-Wei,et al."Huperserines A-E, Lycopodium alkaloids from Huperzia serrata".FITOTERAPIA 99(2014):72-77. |
入库方式： OAI收割
来源：昆明植物研究所
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