Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice
文献类型：期刊论文
| 作者 | Yao, Ran1,2; Chen, Zhaoli1,2; Zhou, Chengcheng1,2; Luo, Mei1,2; Shi, Xuejiao1,2; Li, Jiagen1,2; Gao, Yibo1,2; Zhou, Fang1,2; Pu, Jianxin3 ; Sun, Handong3
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2015 |
| 卷号 | 78期号:1页码:10-16 |
| 通讯作者 | Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; pujianxin@mail.kib.ac.cn ; prof_jiehe@163.com |
| 英文摘要 | Esophageal cancer is the eighth most common cancer in the world and ranks as the sixth leading cause of cancer-related mortality. Esophageal cancer has a poor prognosis partially due to its low sensitivity to chemotherapy agents, and the development of new therapeutic agents is urgently needed. Here, the antitumor activity of a natural ent-kaurane diterpenoid, xerophilusin B (1), which was isolated from Isodon xerophilus, a perennial herb frequently used in Chinese folk medicine for tumor treatment, was investigated. Compound 1 exhibited antiproliferative effects against esophageal squamous cell carcinoma (ESCC) cell lines in a time- and dose-dependent manner with lower toxicity against normal human and murine cell lines. In vivo studies demonstrated that 1 inhibited tumor growth of a human esophageal tumor xenograft in BALB/c nude mice without significant secondary adverse effects, indicating its safety in treating ESCC. Furthermore, 1 induced G2/M cell cycle arrest and promoted apoptosis through mitochondrial cytochrome c-dependent activation of the caspase-9 and caspase-3 cascade pathway in ESCC cell lines. In conclusion, the observations herein reported showed that 1 is a potential chemotherapeutic agent for ESCC and merits further preclinical and clinical investigation for cancer drug development. |
| 学科主题 | Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | CYTOTOXIC ENT-KAURANOIDS ; NF-KAPPA-B ; RABDOSIA-RUBESCENS ; CANCER-CELLS ; ISODON-XEROPHILUS ; DITERPENOIDS ; DEATH ; CHEMORADIOTHERAPY ; ACTIVATION ; PONICIDIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000348617800003 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/20622]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Peking Union Med Coll, Canc Inst & Hosp, Dept Thorac Surg, Beijing 100021, Peoples R China 2.Chinese Acad Med Sci, Beijing 100021, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Ran,Chen, Zhaoli,Zhou, Chengcheng,et al. Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(1):10-16. |
| APA | Yao, Ran.,Chen, Zhaoli.,Zhou, Chengcheng.,Luo, Mei.,Shi, Xuejiao.,...&He, Jie.(2015).Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice.JOURNAL OF NATURAL PRODUCTS,78(1),10-16. |
| MLA | Yao, Ran,et al."Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice".JOURNAL OF NATURAL PRODUCTS 78.1(2015):10-16. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。