The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats
文献类型：期刊论文
| 作者 | Chen,Jijun
|
| 刊名 | HORMONES AND BEHAVIOR
 |
| 出版日期 | 2015 |
| 卷号 | 69页码:106-115 |
| 关键词 | Hypothyroidism Hyperthyroidism Depression Anxiety Brain-derived neurotrophic factor |
| 通讯作者 | Xu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China. ; lxu@vip.163.com ; talktomaomao@163.com |
| 英文摘要 | Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using (131)iodine (I-131) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and triiodothyronine (FT3) significantly decreased in the hypothyroid of rats with single injections of I-131 (5 mCi/kg). These.rats exhibited decreased depression-like behaviors in forced swimming test and sucrose preference tests, as well as decreased anxiety-like behaviors in an elevated plus maze. Diminished levels of brain serotonin (5-HT) and increased levels of hippocampal brain-derived neurotrophic factor (BDNF) were found in the hypothyroid rats compared to the control saline-vehicle administered rats. LT4 treatment reversed the decrease in thyroid hormones and depression-like behaviors. In contrast, hyperthyroidism induced by weekly injections of LT4 (15 mu g/kg) caused a greater than 10-fold increase in serum FT4 and FT3 levels. The hyperthyroid rats exhibited higher anxietyand depression-like behaviors, higher brain 5-HT level, and lower hippocampal BDNF levels than the controls. Treatment with the antidepressant imipramine (15 mg/kg) diminished serum FT4 levels as well as anxietyand depression-like behaviors in the hyperthyroid rats but led to a further increase in brain 5-HT levels, compared with the controls or the hypothyroid rats. Together, our results suggest that hypothyroidism and hyperthyroidism have bidirectional effects on anxiety- and depression-like behaviors in rats, possibly by modulating hippocampal BDNF levels. (C) 2015 Elsevier Inc. All rights reserved. |
| 学科主题 | Behavioral Sciences; Endocrinology & Metabolism |
| 研究领域[WOS] | Behavioral Sciences ; Endocrinology & Metabolism |
| 关键词[WOS] | ADULT HIPPOCAMPAL NEUROGENESIS ; FORCED SWIMMING TEST ; THYROID-HORMONES ; GRAVES-DISEASE ; ANTIDEPRESSANT TREATMENTS ; FOOD-INTAKE ; PLUS-MAZE ; BRAIN ; TRIIODOTHYRONINE ; SEROTONIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352118500012 |
| 公开日期 | 2015-07-07 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/20624]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen,Jijun. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats[J]. HORMONES AND BEHAVIOR,2015,69:106-115. |
| APA | Chen,Jijun.(2015).The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats.HORMONES AND BEHAVIOR,69,106-115. |
| MLA | Chen,Jijun."The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats".HORMONES AND BEHAVIOR 69(2015):106-115. |
入库方式： OAI收割
来源：昆明植物研究所
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