Anti-hepatitis B virus active constituents from Swertia chirayita
文献类型：期刊论文
| 作者 | Zhou, Ning-Jia1,3; Geng, Chang-An1 ; Huang, Xiao-Yan1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Wang, Ju-Le2; Chen, Ji-Jun1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2015 |
| 卷号 | 100页码:27-34 |
| 关键词 | Swertiachiralatone A Swertiachoside A Swertiachirdiol A Swertiachoside B Anti-hepatitis B virus activity Swertia chirayita |
| 通讯作者 | Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; chenjj@mail.kib.ac.cn |
| 英文摘要 | Four new compounds swerdachiralatone A (1), swertiachoside A (2), swertiachirdiol A (3) and swertiachoside B (4), together with twenty-six known ones were isolated from the ethanol extract of Swertia chirayita. Their structures were elucidated by extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR and [alpha](D)). All compounds were evaluated for anti-hepatitis B virus (anti-HBV) activities on HepG 2.2.15 cells line in vitro, of which compounds 14 and 19 showed inhibitory activity on hepatitis B surface antigen (HBsAg) secretion with IC50 values of 031 +/- 0.045 and 1.49 +/- 0.033 mM; compounds 14 and 28 exhibited activity against hepatitis Be antigen (HBeAg) secretion with IC50 values of 0.77 +/- 0.076 and 5.92 +/- 1.02 mM; and eight compounds (8,9,13,14,24-26,29) possessed activity against HBV DNA replication with IC50 values of 0.07-033 mM. In particular (+)-cycloolivil-4'-O-beta-D-glucopyranoside (14) exhibited inhibition not only on the secretions of HBsAg and HBeAg with IC50 values of 031 +/- 0.045 mM (SI = 4.29) and 0.77 +/- 0.076 mM (SI = 1.75), respectively, but also on HBV DNA replication with an IC50 value of 029 +/- 0.034 mM (SI = 4.66). (C) 2014 Elsevier B.V. All rights reserved. |
| 学科主题 | Chemistry, Medicinal; Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | FATTY-ACID ESTER ; CHIRATA BUCH-HAM ; HEPATOPROTECTIVE AGENT ; CHEMICAL-CONSTITUENTS ; GLYCOSIDES ; XANTHONE ; TRITERPENOIDS ; LIGNAN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349881300005 |
| 公开日期 | 2015-07-07 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/20627]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Tibet Univ, Sch Med, Lhasa 850000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Ning-Jia,Geng, Chang-An,Huang, Xiao-Yan,et al. Anti-hepatitis B virus active constituents from Swertia chirayita[J]. FITOTERAPIA,2015,100:27-34. |
| APA | Zhou, Ning-Jia.,Geng, Chang-An.,Huang, Xiao-Yan.,Ma, Yun-Bao.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2015).Anti-hepatitis B virus active constituents from Swertia chirayita.FITOTERAPIA,100,27-34. |
| MLA | Zhou, Ning-Jia,et al."Anti-hepatitis B virus active constituents from Swertia chirayita".FITOTERAPIA 100(2015):27-34. |
入库方式： OAI收割
来源：昆明植物研究所
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