Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish
文献类型：期刊论文
| 作者 | Sun,Hang
|
| 刊名 | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 79期号:4页码:581-586 |
| 关键词 | lignans Scrophulariaceae vascular endothelial growth factor zebrafish Brandisia hancei |
| 通讯作者 | Kim,JS (reprint author),Korea Inst Oriental Med,Herbal Med Res Div,KM Based Herbal Drug Dev Grp,Taejon,South Korea. ; jskim@kiom.re.kr |
| 英文摘要 | In our continuing search for novel antiangiogenic agents, a new lignan glycoside, (7R,8R)-1-(4-O-beta-d-glucopyranosyl-3-methoxyphenyl)-2-{2-methoxy-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol (1), along with three known lignans (2-4), were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-4) were subjected to an in vitro bioassay to evaluate their effects on vascular endothelial growth factor (VEGF)-induced vascular permeability and migration of human retinal endothelial cells (HRECs). Of the compounds tested, compound 1 resulted in the greatest reduction in VEGF-induced vascular permeability by about 31.5% at 10 mu M compared to the VEGF-treated control. In the migration assay, compounds 1 and 2 significantly decreased VEGF-induced HREC migration. Furthermore, zebrafish embryos treated with compounds 1 and 2 showed mild reductions of dorsal longitudinal anastomotic vessel (DLAV) formation. |
| 学科主题 | Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Chemistry, Applied; Food Science & Technology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology |
| 关键词[WOS] | ENDOTHELIAL GROWTH-FACTOR ; PHENYLETHANOIDS ; ANGIOGENESIS ; NEOLIGNANS ; ACTEOSIDE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353479000008 |
| 公开日期 | 2015-07-07 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/20639]  |
| 专题 | 昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun,Hang. Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2015,79(4):581-586. |
| APA | Sun,Hang.(2015).Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,79(4),581-586. |
| MLA | Sun,Hang."Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 79.4(2015):581-586. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。