Bioactive Isoquinoline Alkaloids from Corydalis saxicola
文献类型：期刊论文
| 作者 | Huang, Qiao-Qin1,2; Bi, Jun-Long3; Sun, Qian-Yun4; Yang, Fu-Mei4; Wang, Yue-Hu1 ; Tang, Gui-Hua1; Zhao, Fu-Wei1; Wang, Huan1; Xu, Jin-Jin1; Kennelly, Edward J.5
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2012 |
| 卷号 | 78期号:1页码:65-70 |
| 关键词 | Corydalis saxicola Bunting Fumariaceae isoquinoline alkaloids acetylcholinesterase |
| 英文摘要 | Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)2,-9- dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC(50) values of less than 10 mu M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | MAGNETIC-RESONANCE SPECTROSCOPY ; C-13 NMR ASSIGNMENTS ; PROTOBERBERINE ALKALOIDS ; ABSOLUTE-CONFIGURATIONS ; TETRAZOLIUM SALT ; CONSTITUENTS ; INHIBITORS ; ASSAY ; H-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000299109700012 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/20394]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Heilongtan 650201, Kunming, Peoples R China 2.Yunnan Agr Univ, Coll Landscape & Hort, Kunming 650201, Peoples R China 3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China 4.Chinese Acad Sci, Guiyang, Peoples R China 5.Minzu Univ China, Coll Life & Environm Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Qiao-Qin,Bi, Jun-Long,Sun, Qian-Yun,et al. Bioactive Isoquinoline Alkaloids from Corydalis saxicola[J]. PLANTA MEDICA,2012,78(1):65-70. |
| APA | Huang, Qiao-Qin.,Bi, Jun-Long.,Sun, Qian-Yun.,Yang, Fu-Mei.,Wang, Yue-Hu.,...&Yin, Ge-Fen.(2012).Bioactive Isoquinoline Alkaloids from Corydalis saxicola.PLANTA MEDICA,78(1),65-70. |
| MLA | Huang, Qiao-Qin,et al."Bioactive Isoquinoline Alkaloids from Corydalis saxicola".PLANTA MEDICA 78.1(2012):65-70. |
入库方式： OAI收割
来源：昆明植物研究所
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