Synthesis and Antifungal Activities of New Type beta-Methoxyacrylate-Based Strobilurin Analogues
文献类型：期刊论文
| 作者 | Zhang Xiang ; Liu Huijun ; Gao Yongxin ; Wang Huili ; Guo Baoyuan ; Li Jianzhong |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 30期号:7页码:1517－1524 |
| 关键词 | synthesis strobilurin derivatives antifungal activities substituted pyrimidine SAR |
| ISSN号 | 1001-604X |
| 中文摘要 | Strobilurins have become one of the most important classes of agricultural fungicides. To discover new strobilurin derivatives with high activity against resistant pathogens, a series of novel beta-methoxyacrylate analogues were designed and synthesized by integrating substituted pyrimidine with a strobilurin pharmacophore. The compounds were confirmed and characterized by infrared, 1H nuclear magnetic resonance, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activity against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at the concentration of 50 mu g/mL. Exhilaratingly, compound 1a (R=methyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin. |
| WOS记录号 | WOS:000306562300025 |
| 公开日期 | 2014-11-05 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/7922]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang Xiang,Liu Huijun,Gao Yongxin,et al. Synthesis and Antifungal Activities of New Type beta-Methoxyacrylate-Based Strobilurin Analogues[J]. CHINESE JOURNAL OF CHEMISTRY,2012,30(7):1517－1524. |
| APA | Zhang Xiang,Liu Huijun,Gao Yongxin,Wang Huili,Guo Baoyuan,&Li Jianzhong.(2012).Synthesis and Antifungal Activities of New Type beta-Methoxyacrylate-Based Strobilurin Analogues.CHINESE JOURNAL OF CHEMISTRY,30(7),1517－1524. |
| MLA | Zhang Xiang,et al."Synthesis and Antifungal Activities of New Type beta-Methoxyacrylate-Based Strobilurin Analogues".CHINESE JOURNAL OF CHEMISTRY 30.7(2012):1517－1524. |
入库方式： OAI收割
来源：生态环境研究中心
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