Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties
文献类型：期刊论文
| 作者 | Zhang, Xiang ; Gao, Yong-Xin ; Liu, Hui-Jun ; Guo, Bao-Yuan ; Wang, Hui-Li |
| 刊名 | Chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:8页码:2627-2634 |
| 关键词 | Synthesis Strobilurin derivatives Antifungal activities Pyrimidine |
| ISSN号 | 0253-2964 |
| 中文摘要 | Strobilurins are one of the most important classes of agricultural fungicides. To discover new strobilurin derivatives with high activity against resistant pathogens, a series of novel beta-methoxyacrylate analogues were designed and synthesized by integrating substituted pyrimidine with a strobilurin pharmacophore. The compounds were confirmed and characterized by infrared, H-1 nuclear magnetic resonance, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds (1a-1h) exhibited potent antifungal activities against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at the concentration of 50 mu g/mL. Exhilaratingly, compound 1d (R=3-trifluoromethylphenyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin. |
| WOS记录号 | WOS:000308115300030 |
| 公开日期 | 2014-11-28 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/8192]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Xiang,Gao, Yong-Xin,Liu, Hui-Jun,et al. Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties[J]. Chemistry,2012,33(8):2627-2634. |
| APA | Zhang, Xiang,Gao, Yong-Xin,Liu, Hui-Jun,Guo, Bao-Yuan,&Wang, Hui-Li.(2012).Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties.Chemistry,33(8),2627-2634. |
| MLA | Zhang, Xiang,et al."Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties".Chemistry 33.8(2012):2627-2634. |
入库方式： OAI收割
来源：生态环境研究中心
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