Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon
文献类型：期刊论文
| 作者 | Li, Yan1,2; Liu, Ruiyuan1,3; Shi, Yuanjie4; Zhang, Zhenzhong3; Zhang, Xin1 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:6页码:583-596 |
| 关键词 | Cationic liposomes siRNA therapeutics Poly(carboxybetaine) Polyethylene glycol Accelerated blood clearance (ABC) phenomenon |
| ISSN号 | 1838-7640 |
| 英文摘要 | For efficient delivery of small interfering RNA (siRNA) to the target diseased site in vivo, it is important to design suitable vehicles to control the blood circulation of siRNA. It has been shown that surface modification of cationic liposome/siRNA complexes (lipoplexes) with polyethylene glycol (PEG) could enhance the circulation time of lipoplexes. However, the first injection of PEGylated lipoplexes in vivo induces accelerated blood clearance and enhances hepatic accumulation of the following injected PEGylated lipoplexes, which is known as the accelerated blood clearance (ABC) phenomenon. Herein, we developed zwitterionic poly(carboxybetaine) (PCB) modified lipoplexes for the delivery of siRNA therapeutics, which could avoid protein adsorption and enhance the stability of lipoplexes as that for PEG. Quite different from the PEGylation, the PCBylated lipoplexes could avoid ABC phenomenon, which extended the blood circulation time and enhanced the tumor accumulation of lipoplexes in vivo. After accumulation in tumor site, the PCBylation could promote the cellular uptake and endosomal/lysosomal escape of lipoplexes due to its unique chemical structure and pH-sensitive ability. With excellent tumor accumulation, cellular uptake and endosomal/lysosomal escape abilities, the PCBylated lipoplexes significantly inhibited tumor growth and induced tumor cell apoptosis. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | PEGYLATED LIPOSOMES ; REPEATED INJECTION ; SYSTEMIC DELIVERY ; GENE DELIVERY ; POLYETHYLENE-GLYCOL ; PLA-NANOPARTICLES ; ENDOSOMAL ESCAPE ; NUCLEIC-ACID ; SIRNA ; EFFICIENCY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353064200003 |
| 公开日期 | 2015-07-08 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/16740]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China 4.Univ Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yan,Liu, Ruiyuan,Shi, Yuanjie,et al. Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon[J]. THERANOSTICS,2015,5(6):583-596. |
| APA | Li, Yan,Liu, Ruiyuan,Shi, Yuanjie,Zhang, Zhenzhong,&Zhang, Xin.(2015).Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon.THERANOSTICS,5(6),583-596. |
| MLA | Li, Yan,et al."Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon".THERANOSTICS 5.6(2015):583-596. |
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来源：过程工程研究所
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