Injectable enzymatically crosslinked hydrogels based on a poly(L-glutamic acid) graft copolymer
文献类型：期刊论文
| 作者 | Ren, Kaixuan ; He, Chaoliang ; Cheng, Yilong ; Li,Gao ; Chen,Xuesi |
| 刊名 | polymer chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:17页码:5069-5076 |
| 关键词 | MESENCHYMAL STEM-CELLS SITU FORMING HYDROGELS BIOMEDICAL APPLICATIONS REGENERATIVE MEDICINE TYRAMINE CONJUGATE LINKABLE ALGINATE MICHAEL ADDITION CLICK CHEMISTRY DRUG-DELIVERY DIFFERENTIATION |
| 通讯作者 | he,cl |
| 英文摘要 | enzymatically crosslinked injectable hydrogels based on poly(l-glutamic acid) grafted with tyramine and poly(ethylene glycol) (denoted as plg-g-ta/peg) were developed under physiological conditions in the presence of horseradish peroxidase (hrp) and hydrogen peroxide (h2o2). their gelation time, mechanical properties, swelling behaviors and porous structure were evaluated. the hydrogels were rapidly formed in the presence of low concentrations of hrp and h2o2. the storage modulus of the hydrogels could be well controlled and increased by increasing the concentrations of hrp and h2o2. the average pore-size of the hydrogels varied from 20 to 120 mu m, depending on the h2o2 concentration. in addition, the encapsulated l929 fibroblast cells in the plg-g-ta/peg hydrogels exhibited high viability. after subcutaneous injection of the plg-g-ta/peg solutions containing hrp and h2o2 into the back of rats, the hydrogels were rapidly formed in situ. the hydrogels were found to persist for up to 10 weeks in vivo, and histological analysis indicated that the hydrogels exhibited acceptable biocompatibility. these results suggested that the biocompatible, injectable enzyme-mediated plg-g-ta/peg hydrogels are promising for biomedical applications including tissue engineering scaffolds and drug delivery carriers. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340581200024 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/53004]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ren, Kaixuan,He, Chaoliang,Cheng, Yilong,et al. Injectable enzymatically crosslinked hydrogels based on a poly(L-glutamic acid) graft copolymer[J]. polymer chemistry,2014,5(17):5069-5076. |
| APA | Ren, Kaixuan,He, Chaoliang,Cheng, Yilong,Li,Gao,&Chen,Xuesi.(2014).Injectable enzymatically crosslinked hydrogels based on a poly(L-glutamic acid) graft copolymer.polymer chemistry,5(17),5069-5076. |
| MLA | Ren, Kaixuan,et al."Injectable enzymatically crosslinked hydrogels based on a poly(L-glutamic acid) graft copolymer".polymer chemistry 5.17(2014):5069-5076. |
入库方式： OAI收割
来源：长春应用化学研究所
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