A metabonomic analysis of organ specific response to USPIO administration
文献类型：期刊论文
| 作者 | Feng, Jianghua1,2; Liu, Huili2; Bhakoo, Kishore K.3; Lu, Lehui4; Chen, Zhong1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 32期号:27页码:6558-6569 |
| 关键词 | USPIO HR-MAS (1)H NMR spectroscopy Metabonomics Correlation analysis Biological effect |
| 产权排序 | 第二 |
| 通讯作者 | 陈忠 |
| 英文摘要 | As ultrasmall superparamagnetic particles of iron oxides (USPIO) have been widely used in clinical medicine as MRI contrast agents, hence their potential toxicity and adverse effects following administration have attracted particular attention. In the present study, high resolution magic-angle-spinning (1)H NMR spectroscopy coupled with multivariate statistical analysis was used to directly determine the metabolic consequences of specific-tissues, including kidney, liver and spleen following the intravenous administration of USPIO. Alterations of renal, hepatic and splenic function were reflected by changes in a number of metabolic pathways including small molecules involved in energy, lipid, glucose, and amino acids metabolism. The toxicological potential and metabolic fate of USPIO seems to be linked to their surface chemistry and particle size. Hierarchical principal component analysis was used to explore the multidimensional metabolic relationships between various biological matrices such as kidney, liver, spleen, plasma and urine. Information on the involvement of USPIO in transportation, absorption, biotransformation, biodistribution and secretion was derived from metabolic correlation analysis between different organs and biofluids. Such a metabonomic strategy provides methodology for investigating the potential adverse biological effects of similar nanoparticles on the environmental and human health and assessing the drug interventions on the targeted organ. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 学科主题 | 无线电物理 |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | IRON-OXIDE NANOPARTICLES ; MICROBIOME MOUSE MODEL ; SPECTROSCOPY ; LIVER ; RATS ; MRI ; TISSUE ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000293429700022 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1750]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.ASTAR, Singapore Bioimaging Consortium, Translat Mol Imaging Grp, Singapore 138667, Singapore 4.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Jianghua,Liu, Huili,Bhakoo, Kishore K.,et al. A metabonomic analysis of organ specific response to USPIO administration[J]. BIOMATERIALS,2011,32(27):6558-6569. |
| APA | Feng, Jianghua,Liu, Huili,Bhakoo, Kishore K.,Lu, Lehui,&Chen, Zhong.(2011).A metabonomic analysis of organ specific response to USPIO administration.BIOMATERIALS,32(27),6558-6569. |
| MLA | Feng, Jianghua,et al."A metabonomic analysis of organ specific response to USPIO administration".BIOMATERIALS 32.27(2011):6558-6569. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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