A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade
文献类型：期刊论文
| 作者 | Yi, Ming1; Zhao, Qi1,2; Tang, Jun3; Wang, Canjun4 |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2011-08-01 |
| 卷号 | 157期号:1-3页码:33-42 |
| 关键词 | Ca2+ oscillations GTPase-cycle MAPK cascade Integrated theoretical models Frequency modulation Negative correlation |
| 产权排序 | 第一 |
| 通讯作者 | 易鸣 |
| 英文摘要 | It is known that Ca2+ signal regulates mitogen-activated protein kinase (MAPK) cascade by a central Ras protein in GTPase-cycle. Therefore, we construct an integrated theoretical model comprising Ca2+ oscillations, GTPase-cycle and MAPK cascade modules sequentially. Meanwhile, based on multiple feedback regulations in MAPK cascade, three operation modes of this model are introduced. An extended version of this model is further built when spatial heterogeneity is involved. These models allow us to investigate the very interesting and broad question about the effects of Ca2+ oscillations on the activation of MAPK cascade in both the homogeneous and heterogeneous systems. When the Li-Rinzel model is adopted to simulate endogenous Ca2+ oscillations, our theoretical results illustrate that the appropriate operation mode of MAPK cascade is required for the negative correlation between a decreasing frequency of Ca2+ oscillations and activation of MAPK cascade, which was found in the experiment (S. Kupzig et al. PNAS 102 (2005) 7577-7582). While a piecewise function is used to generate Ca2+ signal to explore much larger range of periods of Ca2+ oscillations, it is found that the negative correlation feature is independent on the operation mode of MAPK cascade. In this case, different operation modes only influence the strength of negative correlation between activation of MAPK cascade and periods of Ca2+ oscillations. The quantitative results may be of great use in analyzing interaction of IP3-Ca2+ and Ras-MAPK signaling pathways, and motivate the further experimental research. (C) 2011 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 学科主题 | 非线性偏微分方程 |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Chemistry, Physical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Chemistry |
| 关键词[WOS] | PROTEIN-KINASE CASCADES ; CALCIUM OSCILLATIONS ; GENE-EXPRESSION ; SYNAPTIC PLASTICITY ; DYNAMICS ; RAS ; PHOSPHORYLATION ; BISTABILITY ; PATHWAYS ; ULTRASENSITIVITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000291903800005 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1757]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.China Univ Min & Technol, Coll Sci, Xuzhou 221008, Peoples R China 4.Baoji Univ Arts & Sci, Nonlinear Res Inst, Baoji 721007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, Ming,Zhao, Qi,Tang, Jun,et al. A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade[J]. BIOPHYSICAL CHEMISTRY,2011,157(1-3):33-42. |
| APA | Yi, Ming,Zhao, Qi,Tang, Jun,&Wang, Canjun.(2011).A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade.BIOPHYSICAL CHEMISTRY,157(1-3),33-42. |
| MLA | Yi, Ming,et al."A theoretical modeling for frequency modulation of Ca2+ signal on activation of MAPK cascade".BIOPHYSICAL CHEMISTRY 157.1-3(2011):33-42. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。