Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings
文献类型：期刊论文
| 作者 | Mazzanti, Mary L.1; Walvick, Ronn P.1; Zhou, Xin1,2; Sun, Yanping1,3; Shah, Niral1; Mansour, Joey1; Gereige, Jessica1; Albert, Mitchell S.1,4 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011-07-15 |
| 卷号 | 6期号:7页码:e21607-e21607 |
| 通讯作者 | Mitchell S. Albert ; 周欣 |
| 产权排序 | 第二 |
| 英文摘要 | In hyperpolarized xenon magnetic resonance imaging (HP Xe-129 MRI), the inhaled spin-1/2 isotope of xenon gas is used to generate the MR signal. Because hyperpolarized xenon is an MR signal source with properties very different from those generated from water-protons, HP Xe-129 MRI may yield structural and functional information not detectable by conventional proton-based MRI methods. Here we demonstrate the differential distribution of HP Xe-129 in the cerebral cortex of the rat following a pain stimulus evoked in the animal's forepaw. Areas of higher HP Xe-129 signal corresponded to those areas previously demonstrated by conventional functional MRI (fMRI) methods as being activated by a forepaw pain stimulus. The percent increase in HP Xe-129 signal over baseline was 13-28%, and was detectable with a single set of pre and post stimulus images. Recent innovations in the production of highly polarized Xe-129 should make feasible the emergence of HP Xe-129 MRI as a viable adjunct method to conventional MRI for the study of brain function and disease. |
| 学科主题 | 波谱学 |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | CEREBRAL-BLOOD-FLOW ; LASER-POLARIZED XE-129 ; POSITRON-EMISSION-TOMOGRAPHY ; FUNCTIONAL MRI ; SOMATOSENSORY STIMULATION ; FOREPAW STIMULATION ; RELAXATION-TIMES ; CARRIER AGENTS ; RAT ; NMR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000292811700001 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1764]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan, Peoples R China 3.Dana Farber Canc Inst, Ctr Biomed Imaging Oncol, Lurie Family Imaging Ctr, Boston, MA 02115 USA 4.Thunder Bay Reg Res Inst, Thunder Bay, ON, Canada |
| 推荐引用方式 GB/T 7714 | Mazzanti, Mary L.,Walvick, Ronn P.,Zhou, Xin,et al. Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings[J]. PLOS ONE,2011,6(7):e21607-e21607. |
| APA | Mazzanti, Mary L..,Walvick, Ronn P..,Zhou, Xin.,Sun, Yanping.,Shah, Niral.,...&Albert, Mitchell S..(2011).Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings.PLOS ONE,6(7),e21607-e21607. |
| MLA | Mazzanti, Mary L.,et al."Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings".PLOS ONE 6.7(2011):e21607-e21607. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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