Bilirubin adsorption on amine/methyl bifunctionalized SBA-15 with platelet morphology
文献类型：期刊论文
| 作者 | Tang, Tao1,4; Li, Xiaoan2; Xu, Yao1; Wu, Dong1; Sun, Yuhan1; Xu, Jun3; Deng, Feng3 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2011-06-01 |
| 卷号 | 84期号:2页码:571-578 |
| 关键词 | Mesoporous materials Blood purification Bilirubin |
| 产权排序 | 第三 |
| 通讯作者 | Xu,Y ; Sun,YH |
| 英文摘要 | To remove bilirubin from human plasma, amine/methyl bifunctionalized SBA-15 materials were directly synthesized from the co-condensation of 3-aminopropylmethyldiethoxysilane and tetraethoxysilane with an amphiphilic block copolymer P123 as template. XRD, N-2 sorption analysis, FTIR and Si-29 MAS NMR were used to identify their well-ordered mesostructure and the grafting of amine and methyl groups on the surface of as-synthesized materials. Both SEM and TEM indicated that the bifunctionalized SBA-15 possessed platelet morphology. This might be attributed to the charge repulsion brought by protonated amine groups and the diminution of hydroxyl groups on the end of silicate-micelles, which passivated the end-to-end anchoring of silicate-micelles along the longitudinal axis. Such a material was investigated as the adsorbent for selective bilirubin removal from human plasma, which showed a high bilirubin clearance of 51.4% within 1.5 h with a little amount of albumin adsorption. The results of hemolysis assay suggested that the bifunctionalized SBA-15 caused serious hemolysis of red blood cells. However, in practical application, plasma separation technique could avoid direct contact between the adsorbent and red blood cells. The further hemeolysis assay proved that the plasma after contacting with the bifunctionalized SBA-15 could not lead to the hemolysis of red blood cells. Thus, the bifunctionalized SBA-15 is expected to be a potential candidate as a clinical hemoperfusion material. (C) 2011 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology |
| 学科主题 | 波谱分析 |
| 类目[WOS] | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Biophysics ; Chemistry ; Materials Science |
| 关键词[WOS] | HUMAN PLASMA ; MESOPOROUS SILICA ; BLOOD PURIFICATION ; REMOVAL ; ALBUMIN ; ADSORBENTS ; MICROBEADS ; PARTICLES ; SYSTEM ; PORES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289395800041 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1779]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Coal Convers, Inst Coal Chem, Taiyuan 030001, Shanxi, Peoples R China 2.Gen Hosp Chengdu Mil Reg, Dept Infect Dis, Chengdu 610083, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Tao,Li, Xiaoan,Xu, Yao,et al. Bilirubin adsorption on amine/methyl bifunctionalized SBA-15 with platelet morphology[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2011,84(2):571-578. |
| APA | Tang, Tao.,Li, Xiaoan.,Xu, Yao.,Wu, Dong.,Sun, Yuhan.,...&Deng, Feng.(2011).Bilirubin adsorption on amine/methyl bifunctionalized SBA-15 with platelet morphology.COLLOIDS AND SURFACES B-BIOINTERFACES,84(2),571-578. |
| MLA | Tang, Tao,et al."Bilirubin adsorption on amine/methyl bifunctionalized SBA-15 with platelet morphology".COLLOIDS AND SURFACES B-BIOINTERFACES 84.2(2011):571-578. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。