Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections
文献类型：期刊论文
| 作者 | Li, Jia V.1; Saric, Jasmina1; Wang, Yulan2; Utzinger, Jurg3; Holmes, Elaine1; Balmer, Oliver4,5,6 |
| 刊名 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
 |
| 出版日期 | 2011 |
| 卷号 | 84期号:1页码:91-98 |
| 产权排序 | 第二 |
| 通讯作者 | E Balmer,O |
| 英文摘要 | Although co infections are common and can have important epidemiologic and evolutionary consequences, studies exploring biochemical effects of multiple strain infections remain scarce We studied metabolic responses of NMRI mice to Trypanosoma brucei brucei single (STIB777AE-Green1 or STIB246BA-Red1) and co infections using a (1)H nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling strategy All T b brucei infections caused an alteration in urinary biochemical composition by day 4 postinfection, characterized by increased concentrations of 2 oxoisocaproate, D 3 hydroxybutyrate, lactate, 4-hydroxyphenylacetate, phenylpyruvate, and 4-hydroxyphenylpyruvate, and decreased levels of hippurate Although there were no marked differences in metabolic signatures observed in the mouse infected with a single or dual strain of T b brucei, there was a slower metabolic response in mice infected with T b brucei green strain compared with mice infected with either the red strain or both strains concurrently Pyruvate phenylpyruvate and hippurate were correlated with parasitemia which might be useful in monitoring responses to therapeutic interventions |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | 波谱分析 |
| 类目[WOS] | Public, Environmental & Occupational Health ; Tropical Medicine |
| 研究领域[WOS] | Public, Environmental & Occupational Health ; Tropical Medicine |
| 关键词[WOS] | GLOBAL METABOLIC-RESPONSES ; MICE ; MARKERS ; PLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285903800017 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1827]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Fac Med, London, England 2.Chinese Acad Sci, State Key Lab Magnet Resononce & Atom & Mol Phys, Wuhan Ctr Mognet Resonance, Wuhan Inst Phys & Math, Wuhan, Peoples R China 3.Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, CH-4051 Basel, Switzerland 4.Univ Basel, Inst Zool, CH-4051 Basel, Switzerland 5.Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4051 Basel, Switzerland 6.Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT USA |
| 推荐引用方式 GB/T 7714 | Li, Jia V.,Saric, Jasmina,Wang, Yulan,et al. Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,2011,84(1):91-98. |
| APA | Li, Jia V.,Saric, Jasmina,Wang, Yulan,Utzinger, Jurg,Holmes, Elaine,&Balmer, Oliver.(2011).Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections.AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,84(1),91-98. |
| MLA | Li, Jia V.,et al."Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections".AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 84.1(2011):91-98. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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