Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior
文献类型：期刊论文
| 作者 | Gong, Rong1,2,3; Ding, Cheng1,4; Hu, Ji1; Lu, Yao1; Liu, Fei5; Mann, Elizabeth6; Xu, Fuqiang5; Cohen, Mitchell B.6; Luo, Minmin1,7 |
| 刊名 | SCIENCE
 |
| 出版日期 | 2011-09-16 |
| 卷号 | 333期号:6049页码:1642-1646 |
| 产权排序 | 第五 |
| 英文摘要 | Midbrain dopamine neurons regulate many important behavioral processes, and their dysfunctions are associated with several human neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD) and schizophrenia. Here, we report that these neurons in mice selectively express guanylyl cyclase-C (GC-C), a membrane receptor previously thought to be expressed mainly in the intestine. GC-C activation potentiates the excitatory responses mediated by glutamate and acetylcholine receptors via the activity of guanosine 3',5'-monophosphate-dependent protein kinase (PKG). Mice in which GC-C has been knocked out exhibit hyperactivity and attention deficits. Moreover, their behavioral phenotypes are reversed by ADHD therapeutics and a PKG activator. These results indicate important behavioral and physiological functions for the GC-C/PKG signaling pathway within the brain and suggest new therapeutic targets for neuropsychiatric disorders related to the malfunctions of midbrain dopamine neurons. |
| 学科主题 | 生物学 |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | DEPENDENT PROTEIN-KINASE ; DEFICIT/HYPERACTIVITY DISORDER ; MICE LACKING ; DOPAMINE ; AMPHETAMINE ; UROGUANYLIN ; RESISTANT ; NEURONS ; PATHWAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294900900047 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1832]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.NIBS, Beijing 102206, Peoples R China 2.Chinese Acad Med Sci, Grad Program, Beijing 100730, Peoples R China 3.Peking Union Med Coll, Beijing 100730, Peoples R China 4.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 6.Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA 7.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Rong,Ding, Cheng,Hu, Ji,et al. Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior[J]. SCIENCE,2011,333(6049):1642-1646. |
| APA | Gong, Rong.,Ding, Cheng.,Hu, Ji.,Lu, Yao.,Liu, Fei.,...&Luo, Minmin.(2011).Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior.SCIENCE,333(6049),1642-1646. |
| MLA | Gong, Rong,et al."Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior".SCIENCE 333.6049(2011):1642-1646. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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