Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent
文献类型：期刊论文
| 作者 | Han, Liang1,2; Li, Jianfeng1,2; Huang, Shixian1,2; Huang, Rongqin1,2; Liu, Shuhuan1,2; Hu, Xing1,2; Yi, Peiwei3; Shan, Dai3; Wang, Xuxia3; Lei, Hao3 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2011-04-01 |
| 卷号 | 32期号:11页码:2989-2998 |
| 关键词 | Receptor-mediated endocytosis Transferrin receptor Peptide GdDTPA Magnetic resonance imaging Contrast agent |
| 产权排序 | 第二 |
| 通讯作者 | Jiang,C |
| 英文摘要 | A tumor-targeting carrier, peptide HAIYPRH (T7)-conjugated polyethylene glycol-modified polyamidoamine dendrimer (PAMAM-PEG-T7) was explored to deliver magnetic resonance imaging (MRI) contrast agents targeting to the tumor cells specifically. Two different types of tumors, liver cancer and early brain glioma model (involved with the blood-brain barrier), were chosen to evaluate the imaging capacity of this contrast agent. PAMAM-PEG-T7 was synthesized, conjugated with diethylene triamine pentaacetic acid (DTPA) and further chelated gadolinium (Gd), yielding GdDTPA-PAMAM-PEG-T7. The result of ICP-AES showed that about 92 Gd ions could be loaded per PAMAM molecule. The calculated longitudinal relaxivity R1 of the GdDTPA-PAMAM-PEG-T7 was 10.7 mm(-1) S-1 per Gd (984.4 mm(-1) S-1 per PAMAM), while that of GdDTPA was only 4.8 mm(-1) S-1. PAMAM-PEG-T7 had better targeting capacity to the liver cancer cells in vitro and in vivo, compared with PAMAM-PEG. The accumulation of PAMAM-PEG-T7 was 162.5% times that of PAMAM-PEG. But for glioma cells, PAMAM-PEG-T7 did not show its specificity. Furthermore, GdDTPA-PAMAM-PEG-T7 could improve the diagnostic efficiency of liver cancer with the enhanced signal (187%), compared to 130% for PAMAM-PEG and 121% for GdDTPA. GdDTPA-PAMAM-PEG-T7 could selectively identify liver cancer but not early glioma. This nanoscaled MRI contrast agent GdDTPA-PAMAM-PEG-T7 might allow for selective and efficient diagnosis of tumors without the natural barrier including liver cancer. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 学科主题 | 波谱分析 |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | IRON-OXIDE NANOPARTICLES ; TRANSFERRIN-RECEPTOR ; MACROMOLECULAR THERAPEUTICS ; HER-2/NEU RECEPTOR ; BRAIN-TUMORS ; CANCER CELLS ; SOLID TUMOR ; IN-VIVO ; DELIVERY ; MRI |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288465800029 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1861]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmaceut, Minist Educ,Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China 2.Fudan Univ, Sch Pharm, Dept Pharmaceut, PLA, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Liang,Li, Jianfeng,Huang, Shixian,et al. Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent[J]. BIOMATERIALS,2011,32(11):2989-2998. |
| APA | Han, Liang.,Li, Jianfeng.,Huang, Shixian.,Huang, Rongqin.,Liu, Shuhuan.,...&Jiang, Chen.(2011).Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent.BIOMATERIALS,32(11),2989-2998. |
| MLA | Han, Liang,et al."Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent".BIOMATERIALS 32.11(2011):2989-2998. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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