Systems Responses of Rats to Aflatoxin B1 Exposure Revealed with Metabonomic Changes in Multiple Biological Matrices
文献类型：期刊论文
| 作者 | Zhang, Limin1; Ye, Yangfang1,2; An, Yanpeng1; Tian, Yuan1,3; Wang, Yulan1; Tang, Huiru1 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 10期号:2页码:614-623 |
| 关键词 | hepatotoxicology metabonomics aflatoxin B1 nuclear magnetic resonance (NMR) |
| 产权排序 | 第一 |
| 英文摘要 | Exposure to aflatoxins causes liver fibrosis and hepatocellular carcinoma posing a significant health risk for human populations and livestock. To understand the mammalian systems responses to aflatoxin-B1 (AFB1) exposure, we analyzed the AFB1-induced metabonomic changes in multiple biological matrices (plasma, urine, and liver) of rats using (1)H NMR spectroscopy together with clinical biochemistry and histopathologic assessments. We found that AFB1 exposure caused significant elevation of glucose, amino acids, and choline metabolites (choline, phosphocholine, and glycerophosphocholine) in plasma but reduction of plasma lipids. AFB1 also induced elevation of liver lipids, amino acids (tyrosine, histidine, phenylalanine, leucine, isoleucine, and valine), choline, and nucleic acid metabolites (inosine, adenosine, and uridine) together with reduction of hepatic glycogen and glucose. AFB1 further caused decreases in urinary TCA cycle intermediates (2-oxoglutarate and citrate) and elevation of gut microbiota cometabolites (phenylacetylglycine and hippurate). These indicated that AFB1 exposure caused hepatic steatosis accompanied with widespread metabolic changes including lipid and cell membrane metabolisms, protein biosynthesis, glycolysis, TCA cycle, and gut microbiota functions. This implied that AFB1 exposure probably caused oxidative-stress-mediated impairments of mitochondria functions. These findings provide an overview of biochemical consequences of AFB1 exposure and comprehensive insights into the metabolic aspects of AFB1-induced hepatotoxicity in rats. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | 生物学 |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | MAGNETIC-RESONANCE-SPECTROSCOPY ; HEPATOCELLULAR-CARCINOMA ; CARBON-TETRACHLORIDE ; GLYCINE CONJUGATION ; BLOOD-PLASMA ; IN-VIVO ; LIVER ; TOXICITY ; ACID ; NMR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286868500021 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1870]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Ningbo Univ, Minist Educ, Key Lab Appl Marine Biotechnol, Ningbo 315211, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Limin,Ye, Yangfang,An, Yanpeng,et al. Systems Responses of Rats to Aflatoxin B1 Exposure Revealed with Metabonomic Changes in Multiple Biological Matrices[J]. JOURNAL OF PROTEOME RESEARCH,2011,10(2):614-623. |
| APA | Zhang, Limin,Ye, Yangfang,An, Yanpeng,Tian, Yuan,Wang, Yulan,&Tang, Huiru.(2011).Systems Responses of Rats to Aflatoxin B1 Exposure Revealed with Metabonomic Changes in Multiple Biological Matrices.JOURNAL OF PROTEOME RESEARCH,10(2),614-623. |
| MLA | Zhang, Limin,et al."Systems Responses of Rats to Aflatoxin B1 Exposure Revealed with Metabonomic Changes in Multiple Biological Matrices".JOURNAL OF PROTEOME RESEARCH 10.2(2011):614-623. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。