Intrauterine growth restriction alters the metabonome of the serum and jejunum in piglets
文献类型：期刊论文
| 作者 | He, Qinghua2; Ren, Pingping2; Kong, Xiangfeng1,3; Xu, Wenxin2; Tang, Huiru2; Yin, Yulong1,3; Wang, Yulan2 |
| 刊名 | MOLECULAR BIOSYSTEMS
 |
| 出版日期 | 2011 |
| 卷号 | 7期号:7页码:2147-2155 |
| 产权排序 | 第二 |
| 英文摘要 | Intrauterine growth restriction (IUGR) is not only an underlying factor for stunted postnatal growth and newborn deaths, but also associated with disease prevalence, such as hypertension and diabetes, in both adult humans and animals. To investigate the metabolic status of IUGR, the differences in serum and jejunal tissue metabonome were examined in IUGR and normal weight 21 day old piglets. IUGR piglets had a significantly lower birth weight (785 +/- 42 g vs. 1451 +/- 124 g), weaned weight (3053 +/- 375 g vs. 6489 +/- 545 g) and average daily gain (108 +/- 16 g vs. 240 +/- 21 g) than normal weight piglets (p < 0.05). IUGR piglets also had a shorter villus height and smaller villus height to crypt depth ratio (p < 0.05) in jejunum. An NMR-based metabonomic study found that serum levels of glycoprotein, albumin and threonine were higher in IUGR than in normal weight piglets, while serum levels of HDL, lipids, unsaturated lipids, glycerophosphorylcholine, myo-inositol, citrate, glutamine and tyrosine were lower in IUGR piglets (p < 0.05). In addition, marked changes in jejunal metabolites, including elevated levels of lipids and unsaturated lipids, and decreased levels of valine, alanine, glutamine, glutamate, choline, glycerophosphorylcholine, trimethylamine-N-oxide, scyllo-inositol, lactate, creatine, glucose, galactose, phenylalanine, tyrosine, glutathione, inosine and taurine were observed in IUGR piglets (p < 0.05). These novel findings indicate that IUGR piglets have a distinctive metabolic status compared to normal weight piglets, including changes in lipogenesis, lipid oxidation, energy supply and utilization, amino acid and protein metabolism, and antioxidant ability; these changes could contribute to impaired growth and jejunal function. |
| 学科主题 | 化学 |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | DIETARY GLUTAMINE SUPPLEMENTATION ; SPINNING H-1-NMR SPECTROSCOPY ; MULTIVARIATE DATA-ANALYSIS ; CHAIN AMINO-ACIDS ; NMR-SPECTROSCOPY ; NEWBORN PIGLETS ; SKELETAL-MUSCLE ; SMALL-INTESTINE ; BIRTH-WEIGHT ; NUTRITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000291559900007 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1883]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Hunan Engn & Res Ctr Anim & Poultry Sci, Changsha 410125, Hunan, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Qinghua,Ren, Pingping,Kong, Xiangfeng,et al. Intrauterine growth restriction alters the metabonome of the serum and jejunum in piglets[J]. MOLECULAR BIOSYSTEMS,2011,7(7):2147-2155. |
| APA | He, Qinghua.,Ren, Pingping.,Kong, Xiangfeng.,Xu, Wenxin.,Tang, Huiru.,...&Wang, Yulan.(2011).Intrauterine growth restriction alters the metabonome of the serum and jejunum in piglets.MOLECULAR BIOSYSTEMS,7(7),2147-2155. |
| MLA | He, Qinghua,et al."Intrauterine growth restriction alters the metabonome of the serum and jejunum in piglets".MOLECULAR BIOSYSTEMS 7.7(2011):2147-2155. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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