Dietary Supplementation with L-Arginine Partially Counteracts Serum Metabonome Induced by Weaning Stress in Piglets
文献类型：期刊论文
| 作者 | He, Qinghua3; Tang, Huiru3; Ren, Pingping3; Kong, Xiangfeng1,2; Wu, Guoyao1,2,4; Yin, Yulong1,2; Wang, Yulan3 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 10期号:11页码:5214-5221 |
| 关键词 | weaning stress arginine metabonomics serum piglets |
| 产权排序 | 第三 |
| 英文摘要 | Arginine plays an important role in preventing intestinal dysfunction and metabolic disorders caused by early weaning stress. However, little is known about how arginine mitigates early weaning stress. This study was conducted to evaluate the effects of weaning stress and dietary arginine supplementation on the metabonome in the serum of piglets using H-1 NMR spectroscopy in conjunction with multivariate data analysis. Thirty castrated male piglets aged 21 d were evenly divided into three groups and fed in three different regimes: sow-fed (SF), weaned with L-alanine supplementation (ALA), and weaned with arginine supplementation (ARG). We found that early weaning stress led to a significantly reduced bodyweight gain (15.6%) and that supplementation with arginine can improve growth rates in piglets by 5.6% (P<0.05). The early weaning stress was associated with marked alterations in lipid and amino acid metabolisms and perturbations in population and/or activities of gut microorganisms, which were manifested in increased levels of organic acids, amino acids, and acetyl-glycoproteins and reduced levels of choline metabolism and lipoproteins. Dietary supplementation with arginine could partially counteract the changes of metabolites induced by weaning stress, such as lipid and amino acid metabolisms. However, arginine was not able to restore disturbed gut microbiota. These results demonstrate the central role of arginine supplementation in regulating the metabolisms of weaned piglets. |
| 学科主题 | 波谱学 |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | AMINO-ACIDS ; SMALL-INTESTINE ; WEANED PIGS ; GLUTAMINE SUPPLEMENTATION ; NMR-SPECTROSCOPY ; SKELETAL-MUSCLE ; NEONATAL PIGS ; RATS ; METABOLISM ; MASS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296414700029 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1893]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Inst Subtrop Agr, Hunan Engn & Res Ctr Anim & Poultry Sci, Changsha 410125, Hunan, Peoples R China 2.Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China 3.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 4.Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA |
| 推荐引用方式 GB/T 7714 | He, Qinghua,Tang, Huiru,Ren, Pingping,et al. Dietary Supplementation with L-Arginine Partially Counteracts Serum Metabonome Induced by Weaning Stress in Piglets[J]. JOURNAL OF PROTEOME RESEARCH,2011,10(11):5214-5221. |
| APA | He, Qinghua.,Tang, Huiru.,Ren, Pingping.,Kong, Xiangfeng.,Wu, Guoyao.,...&Wang, Yulan.(2011).Dietary Supplementation with L-Arginine Partially Counteracts Serum Metabonome Induced by Weaning Stress in Piglets.JOURNAL OF PROTEOME RESEARCH,10(11),5214-5221. |
| MLA | He, Qinghua,et al."Dietary Supplementation with L-Arginine Partially Counteracts Serum Metabonome Induced by Weaning Stress in Piglets".JOURNAL OF PROTEOME RESEARCH 10.11(2011):5214-5221. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。