Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning (1)H NMR Spectroscopy and Multivariate Data Analysis
文献类型：期刊论文
| 作者 | Chen,WX ; Zu,YK ; Huang,Q ; Chen,FE ; Wang,GF ; Lan,WX ; Bai,CX ; Lu,SH ; Yue,Y ; Deng,F |
| 刊名 | MAGNETIC RESONANCE IN MEDICINE
 |
| 出版日期 | 2011 |
| 卷号 | 66期号:6页码:1531-1540 |
| 产权排序 | 第一 |
| 英文摘要 | Lung cancer causes serious health problems. Clinical diagnosis of lung cancer relies on histopathological evalution of tissue specimen. However, extensive knowledge of the metabolic biochemistry of tumors can potentially provide important information for accurate diagnosis of lung cancer. High resolution magic-angle spinning NMR spectroscopy has emerged and be widely acknowledged as an excellent tool in investigating tissue metabolism. Moreover, the combination of high resolution magic-angle spinning NMR technique and multivariate data analysis has become an important metabonomics platform for studying the intact biological tissues. This study reported the metabonomic characteristics of 51 lung tissues from 17 patients with lung cancer using the high resolution magic-angle spinning 1H NMR spectroscopy and the multivariate data analysis methods including principal component analysis and orthogonal partial least squares-discriminant analysis. Clear differences among the metabonomic characteristics of lung cancer tissues at various sites were disclosed. Compared with the adjacent noninvolved tissues, the lung cancer tissues had significantly high levels of aspartate, phosphocholine, glycerophosphocholine and lactate but significantly low levels of glucose and valine. Furthermore, significantly positive (or negative) correlations were observed between the levels of some metabolites such as lactate, fatty acids, valine, phosphocholine, and glycerophosphocholine. Magn Reson Med 66:1531-1540, 2011. ( C) 2011 Wiley Periodicals, Inc. |
| 学科主题 | 波谱学 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1899]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 推荐引用方式 GB/T 7714 | Chen,WX,Zu,YK,Huang,Q,et al. Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning (1)H NMR Spectroscopy and Multivariate Data Analysis[J]. MAGNETIC RESONANCE IN MEDICINE,2011,66(6):1531-1540. |
| APA | Chen,WX.,Zu,YK.,Huang,Q.,Chen,FE.,Wang,GF.,...&Deng,F.(2011).Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning (1)H NMR Spectroscopy and Multivariate Data Analysis.MAGNETIC RESONANCE IN MEDICINE,66(6),1531-1540. |
| MLA | Chen,WX,et al."Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning (1)H NMR Spectroscopy and Multivariate Data Analysis".MAGNETIC RESONANCE IN MEDICINE 66.6(2011):1531-1540. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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