Metabolic alterations in the hamster co-infected with Schistosoma japonicum and Necator americanus
文献类型：期刊论文
| 作者 | Wu, Jun-Fang1,2; Holmes, Elaine3; Xue, Jian4; Xiao, Shu-Hua4; Singer, Burton H.5; Tang, Hui-Ru1; Utzinger, Juerg6; Wang, Yu-Lan1 |
| 刊名 | INTERNATIONAL JOURNAL FOR PARASITOLOGY
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 40期号:6页码:695-703 |
| 关键词 | Co-infection Hamster Metabonomics Necator americanus NMR spectroscopy Schistosoma japonicum |
| 产权排序 | 第一 |
| 英文摘要 | Co-infection with hookworm and schistosomes is a common phenomenon in sub-Saharan Africa, as well as in parts of South America and southeast Asia. As a first step towards understanding the metabolic response of a hookworm-schistosome co-infection in humans, we investigated the metabolic consequences of co-infection in an animal model, using a nuclear magnetic resonance (NMR)-based metabolic profiling technique, combined with multivariate statistical analysis. Urine and serum samples were obtained from hamsters experimentally infected with 250 Necator americanus infective L(3) and 100 Schistosoma japonicum cercariae simultaneously. In the co-infection model, similar worm burdens were observed as reported for single infection models, whereas metabolic profiles of co-infection represented a combination of the altered metabolite profiles induced by single infections with these two parasites. Consistent differences in metabolic profiles between the co-infected and non-infected control hamsters were observed from 4 weeks p.i. onwards. The predominant metabolic alterations in co-infected hamsters consisted of depletion of amino acids, tricarboxylic acid cycle intermediates (e.g. citrate and succinate) and glucose. Moreover, alterations of a series of gut microbial-related metabolites, such as decreased levels of hippurate, 3-hydroxyphenylpropionic acid, 4-hydroxyphenylpropionic acid and tri-methylamine-N-oxide, and increased concentrations of 4-cresol glucuronide and phenylacetylglycine were associated with co-infection. Our results provide a first step towards understanding the metabolic response of an animal host to multiple parasitic infections. (C) 2009 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | 分析化学 |
| 类目[WOS] | Parasitology |
| 研究领域[WOS] | Parasitology |
| 关键词[WOS] | ECHINOSTOMA-CAPRONI INFECTION ; ANCYLOSTOMA-CEYLANICUM ; NIPPOSTRONGYLUS-BRASILIENSIS ; HOOKWORM INFECTION ; MANSONI INFECTION ; CROSS-REACTIVITY ; IMMUNE-RESPONSES ; SPATIAL-PATTERNS ; GOLDEN-HAMSTERS ; RISK-FACTORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277733200007 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1942]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Fac Med, London SW7 2AZ, England 4.Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai 200025, Peoples R China 5.Princeton Univ, Off Populat Res, Princeton, NJ 08544 USA 6.Swiss Trop Inst, Dept Epidemiol & Publ Hlth, CH-4002 Basel, Switzerland |
| 推荐引用方式 GB/T 7714 | Wu, Jun-Fang,Holmes, Elaine,Xue, Jian,et al. Metabolic alterations in the hamster co-infected with Schistosoma japonicum and Necator americanus[J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY,2010,40(6):695-703. |
| APA | Wu, Jun-Fang.,Holmes, Elaine.,Xue, Jian.,Xiao, Shu-Hua.,Singer, Burton H..,...&Wang, Yu-Lan.(2010).Metabolic alterations in the hamster co-infected with Schistosoma japonicum and Necator americanus.INTERNATIONAL JOURNAL FOR PARASITOLOGY,40(6),695-703. |
| MLA | Wu, Jun-Fang,et al."Metabolic alterations in the hamster co-infected with Schistosoma japonicum and Necator americanus".INTERNATIONAL JOURNAL FOR PARASITOLOGY 40.6(2010):695-703. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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