Theoretical study for regulatory property of scaffold protein on MAPK cascade: A qualitative modeling
文献类型：期刊论文
| 作者 | Yi, Ming; Xia, Kelin; Zhan, Meng |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 147期号:3页码:130-139 |
| 关键词 | Scaffold protein Mitogen-activated protein kinases cascade Mathematical model Monte Carlo simulation Regulatory property |
| 产权排序 | 第一 |
| 英文摘要 | An integrated mathematical model, which incorporates scaffold proteins into a mitogen-activated protein kinases cascade, is constructed. By employing Monte Carlo simulation, regulatory property of scaffold protein on signaling ability for the mitogen-activated protein kinases cascade is investigated theoretically. It is found that (i) scaffold binding increases signal amplification if dephosphorylation is slow and decreases amplification if dephosphorylation is rapid. Also, increasing the number of scaffold decreases amplification if dephosphorylation is slow. (ii) The scaffold number can control the timing of kinase activation so that the time flexibility of signaling is enhanced. (iii) It is observed that for slow dephosphorylation case, scaffolds decrease the sharpness of the dose-response curves. While for fast dephosphorylation case, increasing scaffold number decreases the height of response, but the shape of graded response is sustained. Furthermore, the underlying mechanism and the correlation of our results with real biological systems are clarified. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 学科主题 | 非线性偏微分方程 |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Chemistry, Physical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Chemistry |
| 关键词[WOS] | SIGNAL-TRANSDUCTION PATHWAY ; SYSTEMS BIOLOGY ; KINASE PATHWAYS ; INTERNAL NOISE ; COUPLED CELLS ; TIME ; OSCILLATIONS ; RESONANCE ; DYNAMICS ; SPACE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000276666400005 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1988]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, Ming,Xia, Kelin,Zhan, Meng. Theoretical study for regulatory property of scaffold protein on MAPK cascade: A qualitative modeling[J]. BIOPHYSICAL CHEMISTRY,2010,147(3):130-139. |
| APA | Yi, Ming,Xia, Kelin,&Zhan, Meng.(2010).Theoretical study for regulatory property of scaffold protein on MAPK cascade: A qualitative modeling.BIOPHYSICAL CHEMISTRY,147(3),130-139. |
| MLA | Yi, Ming,et al."Theoretical study for regulatory property of scaffold protein on MAPK cascade: A qualitative modeling".BIOPHYSICAL CHEMISTRY 147.3(2010):130-139. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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