Functional changes in the frontal cortex in Parkinson's disease using a rat model
文献类型：期刊论文
| 作者 | Hou, Zhongyu2; Lei, Hao3; Hong, Shuhui4; Sun, Bo1; Fang, Ke3; Lin, Xiangtao1; Liu, Maili3; Yew, David T. W.5; Liu, Shuwei1 |
| 刊名 | JOURNAL OF CLINICAL NEUROSCIENCE
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 17期号:5页码:628-633 |
| 关键词 | Animals Function Magnetic resonance spectroscopy Parkinson's disease |
| 产权排序 | 第三 |
| 英文摘要 | In recent years, investigations of the pathologic mechanism of Parkinson's disease (PD) have mainly concentrated on the basal ganglia. However, recent studies have confirmed that pathological changes in PD are accompanied by functional motor changes of the cerebral cortex. Rats were injected with 6-hydroxydopamine and ascorbic acid in the right substantia nigra. In this rat model of PD, magnetic resonance spectroscopy showed the ratio of N-acetyl-aspartic acid to creatine in a lesion in the right frontal cortex was significantly lower than the same ratio in a control group of rats. The ratio of choline to creatine in a lesion in the right frontal cortex was not significantly different between the PD-model rats and control rats. In addition, the optical densities of neurofilament protein and synaptophysin positive sites decreased significantly on the side of the brain with the injury compared with the side without the injury, and with both sides in the control rats. The density of synapses in the frontal cortex on the lesioned side was decreased compared with the unlesioned side. There were abnormal changes in the presynaptic membrane. postsynaptic membrane and synaptic vesicles, and the typical synaptic structure was no longer apparent on the lesioned side. We hypothesized loss of neurons and synapses, abnormal synaptic structure and neuron and synaptic dysfunction of the frontal cortex with a lesion in the injury side of the frontal cortex in PD-model rats. These changes might have an important role in the pathologic mechanism of PD. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | 波谱分析 |
| 类目[WOS] | Clinical Neurology ; Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | SUPPLEMENTARY MOTOR AREA ; PREFRONTAL CORTEX ; SPECTROSCOPY ; DYSFUNCTION ; BRAINS ; MRI ; PET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000276715300021 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2010]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Shandong Univ, Sch Med, Res Ctr Sect & Imaging Anat, Jinan 250012, Peoples R China 2.Shandong Univ, Dept Med Imaging, Prov Hosp, Jinan 250012, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 4.Shandong Univ, Qianfoshan Hosp, Jinan 250012, Peoples R China 5.Chinese Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Zhongyu,Lei, Hao,Hong, Shuhui,et al. Functional changes in the frontal cortex in Parkinson's disease using a rat model[J]. JOURNAL OF CLINICAL NEUROSCIENCE,2010,17(5):628-633. |
| APA | Hou, Zhongyu.,Lei, Hao.,Hong, Shuhui.,Sun, Bo.,Fang, Ke.,...&Liu, Shuwei.(2010).Functional changes in the frontal cortex in Parkinson's disease using a rat model.JOURNAL OF CLINICAL NEUROSCIENCE,17(5),628-633. |
| MLA | Hou, Zhongyu,et al."Functional changes in the frontal cortex in Parkinson's disease using a rat model".JOURNAL OF CLINICAL NEUROSCIENCE 17.5(2010):628-633. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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