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Advances in Metabolic Profiling of Experimental Nematode and Trematode Infections
文献类型：期刊论文
| 作者 | Wang, Yulan1; Li, Jia V.2; Saric, Jasmina2; Keiser, Jennifer3,4; Wu, Junfang1,5; Utzinger, Juerg4,6; Holmes, Elaine2; Zhou, XN; Bergquist, R; Olveda, R |
| 刊名 | ADVANCES IN PARASITOLOGY, VOL 73
 |
| 出版日期 | 2010 |
| 卷号 | 73期号:1页码:373-404 |
| 产权排序 | 第一 |
| 英文摘要 | Metabonomics, which is the combination of metabolic profiling of biological samples using spectroscopic methods, together with multivariate data analysis, is a powerful approach for biomarker recovery. Moreover, metabonomics holds promise to enhance our understanding of host-parasite interactions at the metabolic level, and therefore provides a framework for discovery of novel targets for diagnostics, drugs and vaccines. In this review, we summarise progress made to date with metabolic profiling strategies applied to different host parasite models in the laboratory. First, we emphasise the application of two parasitic worm infections that are particularly relevant for Southeast Asia and the People's Republic of China, namely the trematode Schistosoma japonicum causing schistosomiasis, and the nematode Necator americanus causing hookworm disease. Next, we review metabolic profiling studies on the liver fluke Fasciola hepatica in the rat model, the intestinal fluke Echinostoma caproni harboured in mice and characterise the metabolic responses in the hamster to a S. japonicum-N. americanus co-infection. We extract parasite-specific biomarkers and distinguish them from a more general response to an infection at the biochemical level. For example, suppression of tricarboxylic acid cycle metabolites is only noted for a Schistosoma spp. infection, whereas alterations in metabolites derived from the gut microbiota are common for all the parasitic infections investigated thus far. Finally, we explore how the insight gained with experimental infections could be transferred to human populations and conclude with a section on research needs with regard to molecular diagnostics in parasitology. |
| 学科主题 | 波谱分析 |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Parasitology |
| 研究领域[WOS] | Parasitology |
| 关键词[WOS] | NUCLEAR-MAGNETIC-RESONANCE ; TRANSMITTED HELMINTH INFECTIONS ; ECHINOSTOMA-CAPRONI INFECTION ; SCHISTOSOMA-MANSONI INFECTION ; NEGLECTED TROPICAL DISEASES ; PATTERN-RECOGNITION METHODS ; ALPHA-KETOADIPIC ACIDURIA ; NMR SPECTROSCOPIC DATA ; PARASITIC DISEASES ; NECATOR-AMERICANUS |
| 收录类别 | BSCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281780800012 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2034]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Peoples R China 2.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Fac Med, London, England 3.Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland 4.Univ Basel, Basel, Switzerland 5.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 6.Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland |
| 推荐引用方式 GB/T 7714 | Wang, Yulan,Li, Jia V.,Saric, Jasmina,et al. Advances in Metabolic Profiling of Experimental Nematode and Trematode Infections[J]. ADVANCES IN PARASITOLOGY, VOL 73,2010,73(1):373-404. |
| APA | Wang, Yulan.,Li, Jia V..,Saric, Jasmina.,Keiser, Jennifer.,Wu, Junfang.,...&Utzinger, J.(2010).Advances in Metabolic Profiling of Experimental Nematode and Trematode Infections.ADVANCES IN PARASITOLOGY, VOL 73,73(1),373-404. |
| MLA | Wang, Yulan,et al."Advances in Metabolic Profiling of Experimental Nematode and Trematode Infections".ADVANCES IN PARASITOLOGY, VOL 73 73.1(2010):373-404. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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