Michaelis-Menten mechanism for single-enzyme and multi-enzyme system under stochastic noise and spatial diffusion
文献类型：期刊论文
| 作者 | Yi, Ming1; Liu, Quan2 |
| 刊名 | PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
 |
| 出版日期 | 2010-09-15 |
| 卷号 | 389期号:18页码:3791-3803 |
| 关键词 | Stochastic noise Spatial diffusion Single enzyme Michaelis-Menten mechanism MAPK cascade |
| 产权排序 | 第一 |
| 英文摘要 | The investigation of enzymatic reaction under stochastic effect and spatial effect is an interesting problem. By virtue of Monte Carlo simulation, the stochastic dynamic of enzyme and the related Michaelis-Menten mechanism with stochastic internal noise and spatial diffusion are explored in this article. (i) For the single-enzyme system, two cases, including the fast phosphorylation case [X. S. Xie, et al., J. Phys. Chem. B 109 (2005) 19068] and slow phosphorylation case [X. S. Xie, et al., Nat. Chem. Biol. 2 (2006) 87] are considered. It is found the micro enzymatic velocity rate shows a rough hyperbolic dependence on the substrate concentration, hence obeys the Michaelis-Menten law qualitatively. In addition, our result reveals that diffusion rate can adjust the Michaelis-Menten curve; especially, it is shown that increasing diffusion rate enhances the micro enzyme rate. (ii) For the multi-enzyme system, a typical example, i.e.. MAPK signaling pathway is used. We apply the Michaelis-Menten mechanism to the MAPK cascade and give a simple comparison for the signaling ability between the Michaelis-Menten mechanism and the single collision mechanism [J. W. Locasale et al., PLOS Comput. Biol. 4 (2008) e1000099]. (C) 2010 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 学科主题 | 偏微分方程 |
| 类目[WOS] | Physics, Multidisciplinary |
| 研究领域[WOS] | Physics |
| 关键词[WOS] | CA2+ OSCILLATIONS ; COUPLED CELLS ; MONTE-CARLO ; DYNAMICS ; TIME ; PATHWAYS ; CASCADES ; SPACE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280385600009 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2044]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Huazhong Agr Univ, Coll Basic Sci, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, Ming,Liu, Quan. Michaelis-Menten mechanism for single-enzyme and multi-enzyme system under stochastic noise and spatial diffusion[J]. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS,2010,389(18):3791-3803. |
| APA | Yi, Ming,&Liu, Quan.(2010).Michaelis-Menten mechanism for single-enzyme and multi-enzyme system under stochastic noise and spatial diffusion.PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS,389(18),3791-3803. |
| MLA | Yi, Ming,et al."Michaelis-Menten mechanism for single-enzyme and multi-enzyme system under stochastic noise and spatial diffusion".PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 389.18(2010):3791-3803. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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