Reduction of Hippocampal N-Acetyl Aspartate Level in Aged APP(Swe)/PS1(dE9) Transgenic Mice Is Associated With Degeneration of CA3 Pyramidal Neurons
文献类型：期刊论文
| 作者 | Xu, Wei1,2; Zhan, Yanqiang3; Huang, Wei1,2; Wang, Xuxia1; Zhang, Sumin3; Lei, Hao1 |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 88期号:14页码:3155-3160 |
| 关键词 | magnetic resonance spectroscopy Alzheimer's disease transgenic amyloid precursor protein hippocampus |
| 产权排序 | 第一 |
| 英文摘要 | Age-related metabolic changes in the hippocampus of APP(Swe)/PS1(dE9) mice were measured with long echo-time in vivo H-1-magnetic resonance spectroscopy (H-1-MRS). Thioflavine S staining and Nissl staining were used to characterize deposition of Ab aggregates and neuronal degeneration in the transgenic animals, respectively. The results showed that the APP(Swe)/PS1(dE9) mice had significantly decreased hippocampal N-acetyl aspartate (NAA)/total creatine (tCr) level at 16 months of age, which was associated with degeneration of and intracellular deposition of thioflavine S-positive materials in hippocampal CA3 pyramidal neurons. The results of this study provide direct evidence showing association among Ab pathology (intracellular deposition of thioflavine S-positive materials), neuronal degeneration, and metabolic changes observable with in vivo H-1-MRS in the hippocampus of APP(Swe)/PS1(dE9) mice. (c) 2010 Wiley-Liss, Inc. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | 波谱分析 |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | APPSWE/PS1DE9 MOUSE MODEL ; AMYLOID-PRECURSOR-PROTEIN ; ALZHEIMERS-DISEASE ; RESONANCE SPECTROSCOPY ; BETA DEPOSITION ; APP/PS1 MICE ; IN-VIVO ; A-BETA ; MUTANT ; APP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000282795200016 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2064]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Huazhong Univ Sci & Technol, Dept Neurol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Wei,Zhan, Yanqiang,Huang, Wei,et al. Reduction of Hippocampal N-Acetyl Aspartate Level in Aged APP(Swe)/PS1(dE9) Transgenic Mice Is Associated With Degeneration of CA3 Pyramidal Neurons[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2010,88(14):3155-3160. |
| APA | Xu, Wei,Zhan, Yanqiang,Huang, Wei,Wang, Xuxia,Zhang, Sumin,&Lei, Hao.(2010).Reduction of Hippocampal N-Acetyl Aspartate Level in Aged APP(Swe)/PS1(dE9) Transgenic Mice Is Associated With Degeneration of CA3 Pyramidal Neurons.JOURNAL OF NEUROSCIENCE RESEARCH,88(14),3155-3160. |
| MLA | Xu, Wei,et al."Reduction of Hippocampal N-Acetyl Aspartate Level in Aged APP(Swe)/PS1(dE9) Transgenic Mice Is Associated With Degeneration of CA3 Pyramidal Neurons".JOURNAL OF NEUROSCIENCE RESEARCH 88.14(2010):3155-3160. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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