Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates
文献类型：期刊论文
| 作者 | Gao, Qiang1,2; Xu, Yao1; Wu, Dong1; Shen, Wanling3; Deng, Feng3 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2010-11-16 |
| 卷号 | 26期号:22页码:17133-17138 |
| 产权排序 | 第三 |
| 英文摘要 | To accomplish pH-controllable drug release on mesoporous carrier, one of the best ways is to graft stimuli-responsive organic molecules around mesopore outlets. In this work, the pH-responsive propyldiethylenetriamine groups (abbreviative phrase: multiamine chains) were grafted around mesopore outlets of mesoporous silica spheres (MSS) and expected to act as pH-responsive gates. To this end, three multiamine-grafted MSS (i.e., NM1, NM2, and NM3) were synthesized under different reaction temperatures and reaction times. The reaction temperature and time for multiamine grafting were 25 degrees C and 12h for NM1, 100 degrees C and 1 h for NM2, and 100 degrees C and 12h for NM3. respectively. Through systematic investigations of TEM, SEM, N-2 adsorption/desorption, TG, and Si-29 NI AS NMR, it was found that NM3 had the highest grafting amount of multiamine chains. It was further confirmed that the multiamine chains around the pore outlets of NM3 played the role of "molecular switch" that could well control the transport of guest drug molecules. In contrast, the multiamine chains around the pore outlets of NM2 and NM3 did not show gate effect. The difference should be decided by the fact whether the grafting amount of multiamine chains around mesopore outlets were sufficient under determined reaction temperature and time. In the tests of in vitro drug release, multiamine-gated MSS (i.e., NM3) showed highly sensitive response to the solution pH. At high pH (pH 7.5), ibuprofen (IBU) in this carrier released rapidly and completely within 2 h; at low pH (pH 4.0 or 5.0), only a small part of the IBU (13 wt %) was slowly released from this carrier anti the most of IOU was effectively confined in mesopores. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 学科主题 | 波谱分析 |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Materials Science |
| 关键词[WOS] | RESPONSIVE CONTROLLED-RELEASE ; GUEST MOLECULES ; DELIVERY-SYSTEM ; MCM-41 ; NANOPARTICLES ; SURFACE ; SIEVES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283837800068 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2066]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Coal Convers, Inst Coal Chem, Taiyuan 030001, Peoples R China 2.China Univ Geosci, Dept Fac Mat Sci & Chem Engn, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Qiang,Xu, Yao,Wu, Dong,et al. Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates[J]. LANGMUIR,2010,26(22):17133-17138. |
| APA | Gao, Qiang,Xu, Yao,Wu, Dong,Shen, Wanling,&Deng, Feng.(2010).Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates.LANGMUIR,26(22),17133-17138. |
| MLA | Gao, Qiang,et al."Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates".LANGMUIR 26.22(2010):17133-17138. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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