Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain
文献类型：期刊论文
| 作者 | Saric, Jasmina1,2; Li, Jia V.1,2; Utzinger, Juerg2,3; Wang, Yulan4; Keiser, Jennifer3,5; Dirnhofer, Stephan6; Beckonert, Olaf1; Sharabiani, Mansour T. A.7; Fonville, Judith M.1; Nicholson, Jeremy K.1 |
| 刊名 | MOLECULAR SYSTEMS BIOLOGY
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 6期号:1页码:396-396 |
| 关键词 | brain Fasciola hepatica immunology metabolic profiling nuclear magnetic resonance spectroscopy |
| 产权排序 | 第四 |
| 英文摘要 | We characterize the integrated response of a rat host to the liver fluke Fasciola hepatica using a combination of 1 H nuclear magnetic resonance spectroscopic profiles (liver, kidney, intestine, brain, spleen, plasma, urine, feces) and multiplex cytokine markers of systemic inflammation. Multivariate mathematical models were built to describe the main features of the infection at the systems level. In addition to the expected modulation of hepatic choline and energy metabolism, we found significant perturbations of the nucleotide balance in the brain, together with increased plasma IL-13, suggesting a shift toward modulation of immune reactions to minimize inflammatory damage, which may favor the co-existence of the parasite in the host. Subsequent analysis of brain extracts from other trematode infection models (i.e. Schistosoma mansoni, and Echinostoma caproni) did not elicit a change in neural nucleotide levels, indicating that the neural effects of F. hepatica infection are specific. We propose that the topographically extended response to invasion of the host as characterized by the modulated global metabolic phenotype is stratified across several bio-organizational levels and reflects the direct manipulation of host-nucleotide balance. Molecular Systems Biology 6: 396; published online 27 July 2010; doi:10.1038/msb.2010.49 Subject Categories: cellular metabolism; molecular biology of disease |
| 学科主题 | 波谱分析 |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | HUMAN-BLOOD-PLASMA ; POLYUNSATURATED FATTY-ACIDS ; GLOBAL METABOLIC-RESPONSES ; NMR-SPECTROSCOPY ; INFLAMMATORY PROCESSES ; TRICHINELLA-SPIRALIS ; BARRIER PERMEABILITY ; LIVER-FAILURE ; DATA SETS ; INFECTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284524200010 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2079]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Fac Med, London SW7 2AZ, England 2.Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland 3.Univ Basel, Basel, Switzerland 4.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 5.Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland 6.Univ Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland 7.Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, Sch Publ Hlth, Fac Med, London SW7 2AZ, England |
| 推荐引用方式 GB/T 7714 | Saric, Jasmina,Li, Jia V.,Utzinger, Juerg,et al. Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain[J]. MOLECULAR SYSTEMS BIOLOGY,2010,6(1):396-396. |
| APA | Saric, Jasmina.,Li, Jia V..,Utzinger, Juerg.,Wang, Yulan.,Keiser, Jennifer.,...&Holmes, Elaine.(2010).Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain.MOLECULAR SYSTEMS BIOLOGY,6(1),396-396. |
| MLA | Saric, Jasmina,et al."Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain".MOLECULAR SYSTEMS BIOLOGY 6.1(2010):396-396. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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