Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent
文献类型：期刊论文
| 作者 | Zhang, Zhi2; He, Rui1; Yan, Kun2; Guo, Qian-ni2; Lu, Yun-guo2; Wang, Xu-xia1; Lei, Hao1; Li, Zao-ying2 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2009-12-01 |
| 卷号 | 19期号:23页码:6675-6678 |
| 关键词 | Synthesis Evaluation Porphyrin Dextran MRI contrast agent |
| 通讯作者 | Lei, H (reprint author), Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China. |
| 英文摘要 | 5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R(1)) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | MAGNETIC-RESONANCE ; NMR ; COMPLEXES ; CARCINOMA ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271430400039 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2142]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhi,He, Rui,Yan, Kun,et al. Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(23):6675-6678. |
| APA | Zhang, Zhi.,He, Rui.,Yan, Kun.,Guo, Qian-ni.,Lu, Yun-guo.,...&Li, Zao-ying.(2009).Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(23),6675-6678. |
| MLA | Zhang, Zhi,et al."Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.23(2009):6675-6678. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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