Systems Metabolic Effects of a Necator americanus Infection in Syrian Hamster
文献类型：期刊论文
| 作者 | Wang, Yulan1; Xiao, Shu-Hua2; Xue, Jian2; Singer, Burton H.3; Utzinger, Juerg4; Holmes, Elaine5 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2009-12-01 |
| 卷号 | 8期号:12页码:5442-5450 |
| 关键词 | Hookworm Necator americanus Hamster Metabolic Profiling Microbiota (1)H NMR Spectroscopy Multivariate Data Analysis |
| 通讯作者 | Wang, YL (reprint author), Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan 430071, Peoples R China. |
| 英文摘要 | Hookworms (Ancylostoma duodenale and Necator americanus) are blood-feeding intestinal nematodes that infect similar to 700 million people worldwide. To further our understanding of the systems metabolic response of the mammalian host to hookworm infection, we employed a metabolic profiling strategy involving the combination of (1)H NMR spectroscopic analysis of urine and serum and multivariate data analysis techniques to investigate the biochemical consequences of a N. americanus infection in the hamster. The infection was characterized by altered energy metabolism, consistent with hookworm-induced anemia. Additionally, disturbance of gut microbiotal activity was associated with a N. americanus infection, manifested in the alterations of microbial-mammalian cometabolites, including phenylacetylglycine, p-cresol glucuronide, 4-hydroxy-3-methyl-phenylpropionic acid, hippurate, 4-hydroxyphenylactate, and dimethylamine. The correlation between worm burden and metabolite concentrations also reflected a changed energy metabolism and gut microbial state. Furthermore, elevated levels of urinary 2-aminoadipate was a characteristic feature of the infection, which may be associated with the documented neurological consequences of hookworm infection. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | TRANSMITTED HELMINTH INFECTIONS ; ECHINOSTOMA-CAPRONI INFECTION ; ORTHOGONAL SIGNAL CORRECTION ; ALPHA-KETOADIPIC ACIDURIA ; METABONOMIC INVESTIGATIONS ; BIOMARKER IDENTIFICATION ; HOOKWORM INFECTION ; LYSINE CATABOLISM ; SPECTROSCOPY ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272339100004 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2146]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan 430071, Peoples R China 2.Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai 200025, Peoples R China 3.Princeton Univ, Off Populat Res, Princeton, NJ 08544 USA 4.Swiss Trop Inst, Dept Publ Hlth & Epidemiol, CH-4002 Basel, Switzerland 5.Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Biomol Med, Dept Surg & Canc, London SW7 2AZ, England |
| 推荐引用方式 GB/T 7714 | Wang, Yulan,Xiao, Shu-Hua,Xue, Jian,et al. Systems Metabolic Effects of a Necator americanus Infection in Syrian Hamster[J]. JOURNAL OF PROTEOME RESEARCH,2009,8(12):5442-5450. |
| APA | Wang, Yulan,Xiao, Shu-Hua,Xue, Jian,Singer, Burton H.,Utzinger, Juerg,&Holmes, Elaine.(2009).Systems Metabolic Effects of a Necator americanus Infection in Syrian Hamster.JOURNAL OF PROTEOME RESEARCH,8(12),5442-5450. |
| MLA | Wang, Yulan,et al."Systems Metabolic Effects of a Necator americanus Infection in Syrian Hamster".JOURNAL OF PROTEOME RESEARCH 8.12(2009):5442-5450. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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