Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics
文献类型：期刊论文
| 作者 | Tang, Huiru1; Xiao, Chaoni1,2,3; Wang, Yulan1 |
| 刊名 | MAGNETIC RESONANCE IN CHEMISTRY
 |
| 出版日期 | 2009-12-01 |
| 卷号 | 47页码:S157-S162 |
| 关键词 | Hyphenation HPLC DAD SPE NMR MS |
| 通讯作者 | Wang, YL (reprint author), Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Magnet Resonance Ctr, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China. |
| 英文摘要 | Metabolite identification is a key step for metabonomics study. A fully automated hyphenation of HPLC-diode-array detector (DAD) mass spectrometry (MS) solid phase extraction (SPE)-NMR spectroscopy (HPLC-DAD-MS-SPE-NMR) is one of the most efficient methods to determine the structure of a given unknown metabolite in a complex mixture (metabonome) and hence represents one of the most important analytical techniques for the further development of metabonomics. In this review, some recent applications of this technique in identifying novel and trace metabolites in plant extracts and drug metabolism have been discussed. Modification of this hyphenated technique, enabling multiple trappings of strong polar metabolites for biofluids, needs further development. Copyright (C) 2009 John Wiley & Sons, Ltd. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Spectroscopy |
| 研究领域[WOS] | Chemistry ; Spectroscopy |
| 关键词[WOS] | NUCLEAR-MAGNETIC-RESONANCE ; GLOBAL METABOLIC-RESPONSES ; MULTIVARIATE DATA-ANALYSIS ; SOLID-PHASE EXTRACTION ; MATRICARIA-RECUTITA L. ; HARPAGOPHYTUM-PROCUMBENS ; LIQUID-CHROMATOGRAPHY ; H-1-NMR SPECTROSCOPY ; BIOMARKER IDENTIFICATION ; MOUSE MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272505700022 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2147]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Magnet Resonance Ctr, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China 2.NW Univ Xian, Coll Life Sci, Xian 710069, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Huiru,Xiao, Chaoni,Wang, Yulan. Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics[J]. MAGNETIC RESONANCE IN CHEMISTRY,2009,47:S157-S162. |
| APA | Tang, Huiru,Xiao, Chaoni,&Wang, Yulan.(2009).Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics.MAGNETIC RESONANCE IN CHEMISTRY,47,S157-S162. |
| MLA | Tang, Huiru,et al."Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics".MAGNETIC RESONANCE IN CHEMISTRY 47(2009):S157-S162. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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