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Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses
文献类型：期刊论文
| 作者 | Zhang, Xiuying2; Wang, Yulan1; Hao, Fuhua1 ; Zhou, Xianghai2; Han, Xueyao2; Tang, Huiru1; Ji, Linong2
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| 刊名 | JOURNAL OF PROTEOME RESEARCH
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| 出版日期 | 2009-11-01 |
| 卷号 | 8期号:11页码:5188-5195 |
| 关键词 | glucose intolerance insulin resistance metabonomics NMR gut microbtota |
| 通讯作者 | Tang, HR (reprint author), Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China. |
| 英文摘要 | Understanding the metabolic basis of glucose intolerances and insulin resistance is essential to facilitate early diagnosis, satisfactory therapies and personalized treatments of type 2 diabetes (T2DM). Here, we analyzed the serum metabolic variations from 231 human participants with normal glucose tolerance (NGT, n = 80, M/F = 34/46, mean age 53 +/- 10 years), impaired glucose regulation (IGR, n = 77, M/F = 33/44, mean age 51 +/- 10 years) and T2DM (n = 74, M/F = 32/42, mean age 51 +/- 9 years) to establish the relationship between the serum metabolite compositions and the development of diabetes By using the proton nuclear magnetic resonance spectroscopy in conjunction with the multivariate data analysis, we found that the development of both glucose intolerances and insulin resistances are closely correlated with the progressive changes of human serum metabonome. Compared with NGT subjects, the IGR and T2DM participants showed clear dysfunctions of choline metabolism, glucose metabolism, lipid and amino acid metabolisms, and disruptions of TCA cycle. The insulin resistance statuses were closely associated with the serum metabonomic changes in terms of glucose, fatty acid and protein/amino acid metabolisms We also found greater metabonomic heterogeneity among the populations with T2DM and high insulin resistance status. These findings provide useful information to bridge the gaps in our understandings to the metabolic alterations associated with the progression of glucose intolerances and insulin resistance status |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | NUCLEAR-MAGNETIC-RESONANCE ; TYPE-2 DIABETES-MELLITUS ; MULTIVARIATE STATISTICAL-ANALYSIS ; GENOME-WIDE ASSOCIATION ; METABOLIC-RESPONSES ; SCHISTOSOMA-MANSONI ; BLOOD-PLASMA ; MODEL ; SPECTROSCOPY ; DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000276949600027 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2161]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Ctr Diabet, Beijing 100044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiuying,Wang, Yulan,Hao, Fuhua,et al. Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses[J]. JOURNAL OF PROTEOME RESEARCH,2009,8(11):5188-5195. |
| APA | Zhang, Xiuying.,Wang, Yulan.,Hao, Fuhua.,Zhou, Xianghai.,Han, Xueyao.,...&Ji, Linong.(2009).Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses.JOURNAL OF PROTEOME RESEARCH,8(11),5188-5195. |
| MLA | Zhang, Xiuying,et al."Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses".JOURNAL OF PROTEOME RESEARCH 8.11(2009):5188-5195. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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