Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal
文献类型：期刊论文
| 作者 | Zhao, Qi1,2; Yi, Ming1; Xia, Kelin1,2; Zhan, Meng1 |
| 刊名 | PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 388期号:19页码:4105-4114 |
| 关键词 | Encoding Decoding Ca2+ oscillation Phosphorylation cycle Combined model Chemical Langevin method |
| 通讯作者 | Zhan, M (reprint author), Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China. |
| 英文摘要 | It is well known that information is encoded in the frequency or amplitude of Ca2+ Signal and then decoded by target protein. However, few models considered both the encoding and decoding procedures of Ca2+ signal. In this work, a minimal Li-Rinzel model is coupled with a phosphorylation-dephosphorylation cycle model, which is used to investigate information transmissions from inositol 1,4,5-trisphosphate (IP3) to target proteins and their relations. We found that the mean target protein activity increases with the IP3 concentration, and at a low level of stimulation, the target protein can be more efficiently activated by an oscillatory signal than a constant signal of the same average calcium if Ca2+ acts cooperatively on the kinase. The internal noise resulting from the finite system size is also taken into account in the combined model. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Physics, Multidisciplinary |
| 研究领域[WOS] | Physics |
| 关键词[WOS] | INTRACELLULAR CALCIUM OSCILLATIONS ; SINGLE-RAT HEPATOCYTES ; KINASE-II ; PHOSPHOLIPASE C-DELTA-1 ; GENE-EXPRESSION ; SPIKE FREQUENCY ; CALMODULIN ; ACTIVATION ; BINDING ; PHENYLEPHRINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268653900014 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2168]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Qi,Yi, Ming,Xia, Kelin,et al. Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal[J]. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS,2009,388(19):4105-4114. |
| APA | Zhao, Qi,Yi, Ming,Xia, Kelin,&Zhan, Meng.(2009).Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal.PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS,388(19),4105-4114. |
| MLA | Zhao, Qi,et al."Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal".PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 388.19(2009):4105-4114. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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