Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity
文献类型：期刊论文
| 作者 | Martin, Francois-Pierre J.; Wang, Yulan; Yap, Ivan K. S.; Sprenger, Norbert; Lindon, John C.; Rezzi, Serge; Kochhar, Sunil; Holmes, Elaine; Nicholson, Jeremy K.1 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
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| 出版日期 | 2009-07-01 |
| 卷号 | 8期号:7页码:3464-3474 |
| 关键词 | high resolution magic angle spinning proton nuclear magnetic resonance spectroscopy human baby microbiota metabolomics microbiome intestine metabolic profiling symbiosis |
| 通讯作者 | Nicholson, JK (reprint author), Nestle Res Ctr, POB 44, CH-1000 Lausanne 26, Switzerland. |
| 英文摘要 | Symbiotic gut microbes can have a significant influence on host health and disease etiology. Here, we assessed the effects of inoculating germfree mice with human baby microbiota (HBM, n = 17) on the biochemical composition of intact intestinal tissues (duodenum, jejunum, ileum, proximal and distal colon) using magic-angle-spinning (1)H NMR spectroscopy. We compared the HBM tissue metabolite profiles with those from conventional (n = 9) and conventionalized (n = 10) mice. Each topographical intestinal region showed a specific metabolic profile that was altered differentially by the various microbiomes, especially for osmolytes. In each animal model, duodenum had higher ethanolamine and myo-inositol, and ileum higher taurine and betaine than other gut regions. HBM mice showed lower taurine and myo-inositol in the colon, and all ex-germfree animals had higher taurine, choline and ethanolamine in the jejunum. Interestingly, the jejunum of HBM mice was marked by a higher glutathione level and lower concentrations of its precursor methionine when compared to other groups. Proximal and distal colon tissues were differentiated in the different microbiome models by the concentrations of bacterial products (higher in conventional animals). These studies show the depth of gut microbiome modulations of the intestinal biochemistry. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | SPINNING H-1-NMR SPECTROSCOPY ; NMR-SPECTROSCOPY ; MOUSE MODEL ; BIOMARKER IDENTIFICATION ; GLUTATHIONE METABOLISM ; GASTROINTESTINAL-TRACT ; DIETARY GLUTATHIONE ; GUT MICROBIOTA ; PROBIOTICS ; NUTRITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000267694600021 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2200]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Nestle Res Ctr, CH-1000 Lausanne 26, Switzerland 2.Univ London Imperial Coll Sci Technol & Med, Dept Biomol Med, Div Surg Oncol Reprod Biol & Anaesthet, Fac Med, London SW7 2AZ, England 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Martin, Francois-Pierre J.,Wang, Yulan,Yap, Ivan K. S.,et al. Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity[J]. JOURNAL OF PROTEOME RESEARCH,2009,8(7):3464-3474. |
| APA | Martin, Francois-Pierre J..,Wang, Yulan.,Yap, Ivan K. S..,Sprenger, Norbert.,Lindon, John C..,...&Nicholson, Jeremy K..(2009).Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity.JOURNAL OF PROTEOME RESEARCH,8(7),3464-3474. |
| MLA | Martin, Francois-Pierre J.,et al."Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity".JOURNAL OF PROTEOME RESEARCH 8.7(2009):3464-3474. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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