Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats
文献类型：期刊论文
| 作者 | Zhang, Xianrong1; Liu, Huilang2; Wu, Junfang2,3; Zhang, Xu2; Liu, Maili2; Wang, Yong4 |
| 刊名 | NEUROCHEMISTRY INTERNATIONAL
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 54期号:8页码:481-487 |
| 关键词 | NMR Metabonomic Hippocampus Temporal cortex Prefrontal cortex Partial least squares-discriminant analysis |
| 通讯作者 | Zhang, XR (reprint author), Wuhan Univ, Sch Basic Med Sci, Dept Physiol, 185 Donghu Rd, Wuhan 430071, Peoples R China. |
| 英文摘要 | The metabolic changes in hippocampus, temporal cortex and prefrontal cortex in SD rats along with aging were explored using a metabonomic approach, which based on high resolution "magic angle spinning" H-1 NMR spectroscopy. The metabolite profiles were analyzed by partial least squares-discriminant analysis, and the results showed that the metabolites of the above three brain regions in old rats were dramatically different from that in the adult and young rats. The old rats showed increased myo-mositol and lactate in all of the three brain regions, and decreased N-acetylaspartate in temporal and frontal cortex, Glutamate-GABA level became imbalance in temporal cortex of old rats. In addition, compared with the adult female rats, male rats had higher levels of N-acetylaspartate, taurine, and creatine in temporal or frontal cortex. The age-related metabolic changes may indicate the early functional alterations of neural cells in these brain regions, especially the temporal cortex. The gender-related metabolic changes suggest the significance of the hormonal regulation in brain metabolism. Our work highlights the potential of metabolic profiling to enhance our understanding of biological mechanisms of brain aging. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 关键词[WOS] | GAMMA-AMINOBUTYRIC-ACID ; N-ACETYLASPARTATE ; OXIDATIVE STRESS ; HUMAN BRAIN ; COGNITIVE IMPAIRMENT ; RECOGNITION MEMORY ; ALZHEIMERS-DISEASE ; NUCLEAR-DNA ; MITOCHONDRIAL ; GLUTAMATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000265945800002 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2201]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Wuhan Univ, Lab Anim Ctr, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xianrong,Liu, Huilang,Wu, Junfang,et al. Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats[J]. NEUROCHEMISTRY INTERNATIONAL,2009,54(8):481-487. |
| APA | Zhang, Xianrong,Liu, Huilang,Wu, Junfang,Zhang, Xu,Liu, Maili,&Wang, Yong.(2009).Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats.NEUROCHEMISTRY INTERNATIONAL,54(8),481-487. |
| MLA | Zhang, Xianrong,et al."Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats".NEUROCHEMISTRY INTERNATIONAL 54.8(2009):481-487. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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