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Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation
文献类型：期刊论文
| 作者 | He, Qinghua1,2,3; Kong, Xiangfeng1,2; Wu, Guoyao2,4; Ren, Pingping5; Tang, Huiru5; Hao, Fuhua5 ; Huang, Ruilin2; Li, Tiejun2; Tan, Bie2; Li, Peng2,4
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| 刊名 | AMINO ACIDS
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 37期号:1页码:199-208 |
| 关键词 | Arginine Metabolomics Serum Pigs Nuclear magnetic resonance spectroscopy |
| 通讯作者 | Yin, YL (reprint author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China. |
| 英文摘要 | Arginine plays an important role regulating nutrient metabolism, but the underlying mechanisms are largely unknown. This study was conducted to determine the effect of dietary arginine supplementation on the metabolome in serum of growing pigs using (1)H nuclear magnetic resonance spectroscopy. Sixteen 120-day-old pigs (48 +/- A 1 kg) were randomly assigned to one of two groups, representing supplementation with 0 or 1.0% l-arginine to corn- and soybean meal-based diets. Serum was collected after a 46-day period of treatment. Dietary arginine supplementation decreased fat deposition and increased protein accretion in the body. Principal component analysis showed that serum concentrations of low density lipoprotein, very low density lipoprotein, and urea were lower, but concentrations of creatinine, tricarboxylic acid cycle metabolites, ornithine, lysine and tyrosine were greater in arginine-supplemented than in control pigs. Additionally, the arginine treatment affected serum concentrations of nitrogenous and lipid signaling molecules (glycerophosphorylcholine and myo-inositol) and intestinal bacterial metabolites (formate, ethanol, methylamine, dimethylamine, acetate, and propionate). These novel findings suggest that dietary arginine supplementation alters the catabolism of fat and amino acids in the whole body, enhances protein synthesis in skeletal muscle, and modulates intestinal microbial metabolism in growing pigs. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | DIABETIC FATTY RATS ; NITRIC-OXIDE ; H-1-NMR SPECTROSCOPY ; AMINO-ACIDS ; BLOOD-PLASMA ; YOUNG-PIGS ; METABONOMICS ; GROWTH ; SYNTHASE ; STRESS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000265685400019 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2226]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China 2.Chinese Acad Sci, Inst Subtrop Agr, Lab Anim Nutr Physiol & Metab, Changsha 410125, Hunan, Peoples R China 3.Chinese CDC, Natl Inst Nutr & Food Safety, Beijing 100050, Peoples R China 4.Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA 5.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Qinghua,Kong, Xiangfeng,Wu, Guoyao,et al. Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation[J]. AMINO ACIDS,2009,37(1):199-208. |
| APA | He, Qinghua.,Kong, Xiangfeng.,Wu, Guoyao.,Ren, Pingping.,Tang, Huiru.,...&Wu, Yongning.(2009).Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation.AMINO ACIDS,37(1),199-208. |
| MLA | He, Qinghua,et al."Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation".AMINO ACIDS 37.1(2009):199-208. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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