Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres
文献类型：期刊论文
| 作者 | Xu, Wujun1,3; Gao, Qiang1,3; Xu, Yao1; Wu, Dong1; Sun, Yuhan1; Shen, Wanfing2,3; Deng, Feng2 |
| 刊名 | POWDER TECHNOLOGY
 |
| 出版日期 | 2009-04-04 |
| 卷号 | 191期号:1-2页码:13-20 |
| 关键词 | Drug release Mesoporous Morphology Silica spheres |
| 通讯作者 | Xu, Y (reprint author), Chinese Acad Sci, State Key Lab Coal Convers, Inst Coal Chem, Taiyuan 030001, Peoples R China. |
| 英文摘要 | Mesoporous silica spheres with controllable particle size were synthesized in mixed ethanol-water solvent. These materials possessed same pore size distribution and pore channel geometry. The amount of ibuprofen (IBU) adsorbed in mesoporous channels increased with the surface area of mesoporous silica spheres. Three kinds of release fluids, simulated intestinal fluid (SIF, pH=7.4), simulated body fluid (SBF, pH=7.4), and simulated gastric fluid (SGF, HCl aqueous solution, pH=1.2) were used to investigate drug release. The effects of particle size and dispersancy of mesoporous spheres on drug release rate were discussed in detail. It was found that larger or agglomerate mesoporous silica spheres could delay the drug release process, which could be attributed to pore-mouth amount and mesopore channel length of mesoporous spheres. Furthermore, to obtain a well controlled drug release system, hydrophobic trimethylsilyl (TMS) groups were functionalized on the surface of mesoporous silica spheres. The release of IBU from TMS-functionalized mesoporous spheres was obviously delayed with the increase of TMS content. (C) 2008 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Chemical |
| 研究领域[WOS] | Engineering |
| 关键词[WOS] | CONTROLLED DRUG-DELIVERY ; PORE-SIZE ; NITROGEN ADSORPTION ; MCM-41 ; IMMOBILIZATION ; MORPHOLOGIES ; MATRICES ; ENZYMES ; SYSTEMS ; PH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264656900003 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2240]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Coal Convers, Inst Coal Chem, Taiyuan 030001, Peoples R China 2.Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Wujun,Gao, Qiang,Xu, Yao,et al. Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres[J]. POWDER TECHNOLOGY,2009,191(1-2):13-20. |
| APA | Xu, Wujun.,Gao, Qiang.,Xu, Yao.,Wu, Dong.,Sun, Yuhan.,...&Deng, Feng.(2009).Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres.POWDER TECHNOLOGY,191(1-2),13-20. |
| MLA | Xu, Wujun,et al."Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres".POWDER TECHNOLOGY 191.1-2(2009):13-20. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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