Neuronal projections from ventral tegmental area to forebrain structures in rat studied by manganese-enhanced magnetic resonance imaging
文献类型：期刊论文
| 作者 | Li, Yingxia1; Fang, Fang1,2; Wang, Xuxia1,2; Lei, Hao1 |
| 刊名 | MAGNETIC RESONANCE IMAGING
 |
| 出版日期 | 2009-04-01 |
| 卷号 | 27期号:3页码:293-299 |
| 关键词 | Magnetic resonance imaging Manganese Brain Rat Ventral tegmental areas Reward circuit |
| 通讯作者 | Lei, H (reprint author), Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China. |
| 英文摘要 | Manganese-enhanced magnetic resonance imaging (MEMRI) has been widely applied to trace neuronal tracts and to monitor morphological and functional responses of specific brain circuits to changes in physiological and/or environmental conditions. In this study, we traced the efferent axonal projections from ventral tegmental area (VTA) to forebrain structures, air integrating part of the reward circuit implicated in drug addiction.. in rats using MEMRI. Urethane- and chloral hydrate-anesthetized rats received injection of 100 nl of 200 mM MnCl(2) solution into the right VTA. Mn(2+)-induced signal enhancements were monitored 24 h after injection. The dose of MnCl(2) injection was shown, by histological evaluation, to have minor toxic effects to the neurons in/near the injection site. Dynamic Mn(2+)-induced signal intensity changes in urethane-anesthetized rats during a 24-h period were fit to a sigmoidal function to obtain parameters slope and t(50), which describe the dynamics of apparent Mn(2+) accumulation. The results showed that most of the forebrain structures known to receive neuronal projections from the VTA, including prefrontal cortex, nucleus accumbens, globus pallidus and caudate putaman, were enhanced at 24 It after injection of MnCl(2) into the ipsilateral VTA, and anesthesia seemed have little effects on the amount of Mn(2+) being transported from the VTA to these structures. (C) 2009 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | GABA-CONTAINING NEURONS ; IN-VIVO ; DOPAMINE NEURONS ; HORSERADISH-PEROXIDASE ; HIPPOCAMPAL-FORMATION ; MOLECULAR-MECHANISMS ; PREFRONTAL CORTEX ; NUCLEUS-ACCUMBENS ; T-1-WEIGHTED MRI ; BASAL FOREBRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264581000001 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/2246]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yingxia,Fang, Fang,Wang, Xuxia,et al. Neuronal projections from ventral tegmental area to forebrain structures in rat studied by manganese-enhanced magnetic resonance imaging[J]. MAGNETIC RESONANCE IMAGING,2009,27(3):293-299. |
| APA | Li, Yingxia,Fang, Fang,Wang, Xuxia,&Lei, Hao.(2009).Neuronal projections from ventral tegmental area to forebrain structures in rat studied by manganese-enhanced magnetic resonance imaging.MAGNETIC RESONANCE IMAGING,27(3),293-299. |
| MLA | Li, Yingxia,et al."Neuronal projections from ventral tegmental area to forebrain structures in rat studied by manganese-enhanced magnetic resonance imaging".MAGNETIC RESONANCE IMAGING 27.3(2009):293-299. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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