Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats
文献类型：期刊论文
| 作者 | Zhang, Xianrong1; Wu, Junfang2; Liu, Huilang2,3; Zhang, Xu2 |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2013-04-24 |
| 卷号 | 1507页码:28-34 |
| 关键词 | NMR Metabonomic Striatum Cerebellar cortex Partial least squares-discriminant analysis |
| 英文摘要 | In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomic approach based on high resolution "magic angle spinning" H-1-NMR spectroscopy and partial least squares-discriminant analysis. It was found that there were increased myo-inositol and lactate, and decreased taurine in these two brain regions of old rats. The above changes may be a marker for alterations of neuronal cells, which reduce fine motor control. Besides, some of the metabolites are gender-related and region-specific. Old female rats had decreased glutamate and increased creatine in striatum, while old male rats had increased choline in striatum, and increased GABA in cerebellar cortex, respectively. However, further analyses showed that most of the metabolites in male rats were not distinctively different with those of female ones except choline, which was in a relative lower level in striatum of male rats. All this results suggest that energy metabolism is an important indication of age-related change, which is not only in male, but also in female rats. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | GAMMA-AMINOBUTYRIC-ACID ; BASAL GANGLIA ; MULTIPLE-SCLEROSIS ; PARALLEL FIBERS ; AGING BRAIN ; IN-VIVO ; SPECTROSCOPY ; DISEASE ; GLUTAMATE ; CREATINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318326100004 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/803]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Wuhan Univ, Dept Physiol, Sch Basic Med Sci, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Kunming Inst Zool, Kunming 650223, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xianrong,Wu, Junfang,Liu, Huilang,et al. Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats[J]. BRAIN RESEARCH,2013,1507:28-34. |
| APA | Zhang, Xianrong,Wu, Junfang,Liu, Huilang,&Zhang, Xu.(2013).Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats.BRAIN RESEARCH,1507,28-34. |
| MLA | Zhang, Xianrong,et al."Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats".BRAIN RESEARCH 1507(2013):28-34. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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