A choline derivate-modified nanoprobe for glioma diagnosis using MRI
文献类型：期刊论文
| 作者 | Li, Jianfeng1; Huang, Shixian1; Shao, Kun1; Liu, Yang1; An, Sai1; Kuang, Yuyang1; Guo, Yubo1; Ma, Haojun1; Wang, Xuxia2; Jiang, Chen1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2013-04-08 |
| 卷号 | 3 |
| 英文摘要 | Gadolinium (Gd) chelate contrast-enhanced magnetic resonance imaging (MRI) is a preferred method of glioma detection and preoperative localisation because it offers high spatial resolution and non-invasive deep tissue penetration. Gd-based contrast agents, such as Gd-diethyltriaminepentaacetic acid (DTPA-Gd, Magnevist), are widely used clinically for tumor diagnosis. However, the Gd-based MRI approach is limited for patients with glioma who have an uncompromised blood-brain barrier (BBB). Moreover, the rapid renal clearance and non-specificity of such contrast agents further hinders their prevalence. We present a choline derivate (CD)-modified nanoprobe with BBB permeability, glioma specificity and a long blood half-life. Specific accumulation of the nanoprobe in gliomas and subsequent MRI contrast enhancement are demonstrated in vitro in U87 MG cells and in vivo in a xenograft nude model. BBB and glioma dual targeting by this nanoprobe may facilitate precise detection of gliomas with an uncompromised BBB and may offer better preoperative and intraoperative tumor localization. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | BLOOD-BRAIN-BARRIER ; MALIGNANT GLIOMA ; CONTRAST AGENTS ; NANOPARTICLES ; TRANSPORTER ; DELIVERY ; PATHOLOGY ; ANALOGS ; CELLS ; PET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317182000001 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/811]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jianfeng,Huang, Shixian,Shao, Kun,et al. A choline derivate-modified nanoprobe for glioma diagnosis using MRI[J]. SCIENTIFIC REPORTS,2013,3. |
| APA | Li, Jianfeng.,Huang, Shixian.,Shao, Kun.,Liu, Yang.,An, Sai.,...&Jiang, Chen.(2013).A choline derivate-modified nanoprobe for glioma diagnosis using MRI.SCIENTIFIC REPORTS,3. |
| MLA | Li, Jianfeng,et al."A choline derivate-modified nanoprobe for glioma diagnosis using MRI".SCIENTIFIC REPORTS 3(2013). |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。