Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation
文献类型：期刊论文
| 作者 | Gao, Lifeng1,2; Yang, Sheng-Tao3; Li, Shaorui1,2; Meng, Yuguang1,2; Wang, Haifang4; Lei, Hao1 |
| 刊名 | JOURNAL OF APPLIED TOXICOLOGY
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 33期号:10页码:1079-1088 |
| 关键词 | zinc oxide nanoparticles toxicity olfactory epithelium magnetic resonance imaging |
| 英文摘要 | With the increased applications of zinc oxide (ZnO) nanoparticles (NPs), the toxicity of ZnO NPs arouses great concerns from the nano community and the general public. In this study, we report the toxicity of ZnO NPs (30 nm) to the rat olfactory system after intranasal instillation revealed by non-invasive magnetic resonance imaging (MRI). MRI scans were performed on a 4.7-T scanner at 1, 2, 3 and 7 days post-exposure, and the histological changes of the rat olfactory epithelium were evaluated. The influences of chemical component and dispersant of the NPs were also investigated. In addition, an olfactory behavior test was performed. The MRI and histological results indicated that ZnO NPs induced significant damages to the olfactory epithelium, including disruption of the olfactory epithelial structures and inflammation. The destruction of mitochondria in epithelial cells was observed under transmission electron microscopy (TEM), suggesting that the possible toxicological mechanism might involve cellular energy metabolic dysfunction. Further, the lesion of the olfactory epithelium disturbed sniffing behaviors of the treated animals. The results suggest that MRI is potentially useful as a screening tool to assess the consequence of occupational exposure of ZnO NPs. Caution should therefore be taken during the use and disposal of ZnO NPs to prevent the unintended public health impacts. Copyright (C) 2012 John Wiley & Sons, Ltd. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Toxicology |
| 研究领域[WOS] | Toxicology |
| 关键词[WOS] | ZNO NANOPARTICLES ; TOXICOLOGICAL IMPACT ; TIO2 NANOPARTICLES ; INHALED ULTRAFINE ; PARTICLES ; CELLS ; TRANSLOCATION ; INHIBITION ; INHALATION ; RESPONSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322331900006 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/896]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Southwest Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China 4.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Lifeng,Yang, Sheng-Tao,Li, Shaorui,et al. Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation[J]. JOURNAL OF APPLIED TOXICOLOGY,2013,33(10):1079-1088. |
| APA | Gao, Lifeng,Yang, Sheng-Tao,Li, Shaorui,Meng, Yuguang,Wang, Haifang,&Lei, Hao.(2013).Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation.JOURNAL OF APPLIED TOXICOLOGY,33(10),1079-1088. |
| MLA | Gao, Lifeng,et al."Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation".JOURNAL OF APPLIED TOXICOLOGY 33.10(2013):1079-1088. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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