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NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo
文献类型：期刊论文
| 作者 | Hou, Yi1; Qiao, Ruirui1; Fang, Fang2; Wang, Xuxia2; Dong, Chengyan3; Liu, Kan4,5; Liu, Chunyan1; Liu, Zhaofei3; Lei, Hao2; Wang, Fan3 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2013 |
| 卷号 | 7期号:1页码:330-338 |
| 关键词 | NaGdF4 nanoparticles ligand exchange T1 contrast agent MR molecular imaging probe intraperitoneal tumor xenografts |
| 英文摘要 | Differently sized NaGdF4 nanocrystals with narrow particle size distributions were synthesized by a high temperature approach. Upon ligand exchange, the as-prepared hydrophobic NaGdF4 nanocrystals were transferred into water by using asymmetric PEGs simultaneously bearing phosphate and maleimide groups. Further investigations demonstrated that the water-soluble NaGdF4 nanocrystals, coated by PEG bearing two phosphate groups on the same side, exhibit not only excellent colloidal stability in water and PBS buffer, but also higher T1 relaxivity than Gd-DTPA (Magnevist). Through "click" reaction between the maleimide residue on particle surface and thiol group from the partly reduced anti-EGFR monoclonal antibody (mAb), NaGdF4 PEG-mAb nanoprobes were constructed, and their biocompatibility and binding specificity were evaluated through in vitro experiments. A series of in vivo experiments were then carried out for detecting Intraperitoneal tumor xenografts in nude mice by using magnetic resonance (MR) imaging technique. The results revealed that the NaGdF4 PEG-mAb probes possessed satisfying tumor-specific targeting ability and strong MR contrast enhancement effects. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | MRI CONTRAST AGENTS ; GOLD NANOPARTICLES ; GADOLINIUM ; NANOCRYSTALS ; CANCER ; NANOPROBES ; ANTIBODY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314082800037 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/949]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Peking Univ, Med Isotopes Res Ctr, Beijing 100083, Peoples R China 4.CAMS, Canc Hosp, Beijing 100021, Peoples R China 5.PUMC, Beijing 100021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Yi,Qiao, Ruirui,Fang, Fang,et al. NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo[J]. ACS NANO,2013,7(1):330-338. |
| APA | Hou, Yi.,Qiao, Ruirui.,Fang, Fang.,Wang, Xuxia.,Dong, Chengyan.,...&Gao, Mingyuan.(2013).NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo.ACS NANO,7(1),330-338. |
| MLA | Hou, Yi,et al."NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo".ACS NANO 7.1(2013):330-338. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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