Voxel-Based Diffusion Tensor Imaging of an APP/PS1 Mouse Model of Alzheimer's Disease
文献类型：期刊论文
| 作者 | Shu, Xiaogang1; Qin, Yuan-Yuan2; Zhang, Shun2; Jiang, Jing-Jing2; Zhang, Yan2; Zhao, Ling-Yun2; Shan, Dai3; Zhu, Wen-Zhen2 |
| 刊名 | MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 48期号:1页码:78-83 |
| 关键词 | Alzheimer's Disease Diffusion Tensor Imaging Ultrastructure Gray Matter White Matter |
| 英文摘要 | Increasing evidence has demonstrated that white matter (WM) disruptions, due to the injury of the axon and myelin, play an important role in the pathogenesis of Alzheimer's disease (AD). Diffusion tensor imaging (DTI) is a sensitive modality to evaluate the WM integrity in both AD patients and animal models. In this study, an advanced DTI modality, employing a 7.0-T magnetic resonance imaging system, was used to analyze WM changes across the whole brain of an amyloid precursor protein/presenilin 1 (APP/PS1) mouse model. A voxel-based analysis was used to compare the quantitative DTI parameters automatically in both APP/PS1 mice (n = 9) and wild-type (WT) controls (n = 9). After DTI examination, the ultrastructure analysis was compared with DTI findings. Compared with WT controls, gray matter (GM) areas in APP/PS1 mice such as the cingulate cortex and the striatum showed significant fractional anisotropy (FA) and axial diffusivity (DA) increase, while the thalamus only showed a significant FA increase (p < 0.01). Similarly, a significant mean diffusivity, DA, and radial diffusivity increase was observed in the bilateral neocortex (p < 0.01). The left hippocampus only showed significant FA increase in APP/PS1 mice (p < 0.01). The changes in WM regions were detected in the forceps minor of the corpus callosum, the anterior part of the anterior commissure, and the internal capsule, with a significant FA or DA increase (p < 0.01). Abnormalities derived from diffusion measurements were in-line with the ultrastructure findings, including extensive pathological damage of the neurons, neutrophils, and vessels. In conclusion, voxel-based diffusion tensor imaging can detect diffusion alterations not only in GM but also in WM areas in AD models, reflecting the extensive pathological changes of AD. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | WHITE-MATTER INTEGRITY ; CORPUS-CALLOSUM ; TRANSGENIC MICE ; BRAIN ; MRI ; ABNORMALITIES ; HIPPOCAMPUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322138900008 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/951]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Gastrointestinal Surg, Union Hosp, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Dept Radiol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China 3.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Xiaogang,Qin, Yuan-Yuan,Zhang, Shun,et al. Voxel-Based Diffusion Tensor Imaging of an APP/PS1 Mouse Model of Alzheimer's Disease[J]. MOLECULAR NEUROBIOLOGY,2013,48(1):78-83. |
| APA | Shu, Xiaogang.,Qin, Yuan-Yuan.,Zhang, Shun.,Jiang, Jing-Jing.,Zhang, Yan.,...&Zhu, Wen-Zhen.(2013).Voxel-Based Diffusion Tensor Imaging of an APP/PS1 Mouse Model of Alzheimer's Disease.MOLECULAR NEUROBIOLOGY,48(1),78-83. |
| MLA | Shu, Xiaogang,et al."Voxel-Based Diffusion Tensor Imaging of an APP/PS1 Mouse Model of Alzheimer's Disease".MOLECULAR NEUROBIOLOGY 48.1(2013):78-83. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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