Diffusion tensor magnetic resonance imaging reveals visual pathway damage that correlates with clinical severity in glaucoma
文献类型：期刊论文
| 作者 | Chen, Zhiqi1; Lin, Fuchun3; Wang, Junming1; Li, Zheng1; Dai, Hui2; Mu, Ketao2; Ge, Jian4; Zhang, Hong1 |
| 刊名 | CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 41期号:1页码:43-49 |
| 关键词 | diffusion tensor imaging neurodegenerative disease primary open-angle glaucoma tract-based spatial statistics |
| 英文摘要 | Background: To investigate nerve fibre damage of the visual pathway in patients with primary open-angle glaucoma using tract-based spatial statistical analysis of diffusion tensor imaging and correlate these measures with the clinical severity of glaucoma. Design: Cross-sectional study. Participants: Twenty-five individuals with primary open-angle glaucoma and 24 healthy controls were recruited. Methods: All subjects underwent detailed ophthalmological examinations, including the cup-to-disc ratio, retinal nerve fibre layer thickness and visual fields test. Diffusion tensor imaging of the visual pathway was performed using a 3.0-T magnetic resonance scanner. Main Outcome Measures: Diffusivity changes of the nerve fibres in the visual pathway were calculated through tract-based spatial statistical analysis. The mean diffusivity and fractional anisotropy were assessed and compared with ophthalmological measurements. Results: Compared with controls, bilateral optic tracts and optic radiations in primary open-angle glaucoma patients showed significantly decreased fractional anisotropy and increased mean diffusivity (P < 0.05). In the glaucoma group, the fractional anisotropy of the optic tracts and optic radiations varied consistently with the cup-to-disc ratio, retinal nerve fibre layer thickness and visual function analysis, respectively (P < 0.05). The mean diffusivity of the optic tracts correlated with these ophthalmological measurements (P < 0.05). However, no significant correlation was observed between the mean diffusivity of the optic radiations and the ophthalmological measurements (P > 0.05). Conclusions: The optic tracts and optic radiations of primary open-angle glaucoma patients demonstrated radiological evidence of neurodegeneration. This varied with damage to the optic disc and with the loss of visual function. Tract-based spatial statistical analysis of diffusion tensor imaging is an objective and effective tool for detecting the loss of cortical nerve fibres in primary open-angle glaucoma. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Ophthalmology |
| 研究领域[WOS] | Ophthalmology |
| 关键词[WOS] | LATERAL GENICULATE-NUCLEUS ; OPEN-ANGLE GLAUCOMA ; OPTIC-NERVE ; NEURAL DEGENERATION ; MOUSE MODEL ; BLOOD-FLOW ; DISEASE ; CORTEX ; BRAIN ; NEURODEGENERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314181000008 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/969]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Ophthalmol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China 2.Huazhong Univ Sci & Technol, Dept Radiol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan, Peoples R China 4.Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510275, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zhiqi,Lin, Fuchun,Wang, Junming,et al. Diffusion tensor magnetic resonance imaging reveals visual pathway damage that correlates with clinical severity in glaucoma[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2013,41(1):43-49. |
| APA | Chen, Zhiqi.,Lin, Fuchun.,Wang, Junming.,Li, Zheng.,Dai, Hui.,...&Zhang, Hong.(2013).Diffusion tensor magnetic resonance imaging reveals visual pathway damage that correlates with clinical severity in glaucoma.CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,41(1),43-49. |
| MLA | Chen, Zhiqi,et al."Diffusion tensor magnetic resonance imaging reveals visual pathway damage that correlates with clinical severity in glaucoma".CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 41.1(2013):43-49. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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